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@sigtrans-sttt.bsky.socialSep 25, 2026, 6:00 AM

Researchers harness the intracellular #Immunoproteasome as a disease-selective trigger, coupling #MMAE to an immunoproteasome-selective peptide to enable preferential drug release in #Cancer cells and suppress small cell #LungCancer. @uclacollege.bsky.social
#OpenAccess: doi.org/10.1038/s413...

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics
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