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@philoneurosci.bsky.socialSep 28, 2026, 10:21 PM

A #hypothalamic #neuronal population coordinates #metabolic adaptations to cold: Neuron www.cell.com/neuron/fullt...

@thelancetendo.bsky.socialSep 15, 2026, 9:11 AM

Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets www.thelancet.com/journals/lan...
#hyperphagia

Variants of genes that affect different components of the leptin–melanocortin pathways cause monogenic obesity. Identified mutations in monogenic forms of hypothalamic obesity are denoted by an asterisk. LEP=leptin. LEPR=leptin receptor. POMC=proopiomelanocortin. PVH=paraventricular hypothalamus. α-MSH=alpha melanocyte-stimulating hormone. MC3R=melanocortin receptor 3. MC4R=melanocortin receptor 4. PCSK1=proprotein convertase aubtilisin–kexin type 1. NCOA1=nuclear receptor coactivator 1 (also known as SRC-1, for steroid receptor coactivator-1). SH2B1=SH2B adaptor protein 1. ALMS1=Alstrom syndrome protein 1. BBSx=Bardet-Bieldt syndrome-related genes. SEMA3x=semaphorin 3 (A–G) genes. HTR2C=serotonin 2c receptor. 3V=third ventricle.
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