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Colourful i-Base graphic. The main text reads: Major update to US HIV treatment guidelines: we summarise the main changes. At the top is i-Base’s website address: I hyphen base dot info. A smaller rectangle in the bottom right, reads: HIV news. 2026. There are various dotted patterns. The colours used in the image are two shades of red, mustard, orange, dark blue, brown, two shades of green, turquoise and white.