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@jamaotolaryngology.com Sep 7, 2026, 4:00 PM

For #HeadAndNeckSquamousCellCarcinoma surveillance, tissue-informed #ctDNA positivity was sometimes the first sign of recurrence and showed high positive and negative predictive value.

A three-part graph. A) Swimmer plot of patient surveillance shows ctDNA test results (negative: blue squares; positive: red circles) & recurrence (red X) over time. B) Patient 1's ctDNA rises from negative to >2 MTM/mL over 16 months, with PET/CT/Biopsy. C) Patient 2's ctDNA fluctuates around 1.5 MTM/mL over 13 months, with PET/CT.

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