An aptly titled paper shows, for the first time, the significance of heterogeneities of gene expression in the construction of complex systems : fate decisions are group decisions. Previously @biorxivpreprint
cell.com/cell/fulltex... #MustRead #Gastruloids
@Jshendure lab

This observation others w/ #gastruloids on how Matrigel elicits the emergence of somites morphogenesis where somite GRNs are in place or on how spinal cord can refine the patterning of somites. All about higher order organizing interactions between cell populations. #Codevelopment #NotInTheGenes

Intriguing set of observations on how ‘dual-aggregate gastruloids’ lead to the emergence of foregut-pharyngeal mesoderm co-development and patterning www.biorxiv.org/content/10.6...
#gastruloids #MustRead

Thank you @ramiro-alberio.bsky.social for a great day at @uniofnottingham.bsky.social biosciences with much to think about on farm animals #gastruloids and for sharing much of the history at the centre of the Midlands

On the usefulness of #gastruloids as a discovery tool for the exploration of early mammalian development. Previously as #preprint now out after PR
www.nature.com/articles/s41...