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@abfbrain.bsky.socialSep 22, 2026, 10:00 PM

With an ABF grant, Dr. Caghan Kizil has been studying APOE4, the strongest genetic risk factor for Alzheimer’s. His team found #APOE4 responds to inflammation by producing #fibronectin. Targeting the #inflammation could help prevent #Alzheimers.

A new study offers a clue as to why some people with the APOE4 gene develop Alzheimer’s and others don’t. Dr. Caghan Kizil, recipient of a 2026 Cure One Cure Many Catalyst Award in Neuroinflammation, and his team shed light on why some people with the strongest genetic risk for Alzheimer’s never develop the disease.The genetic variant APOE4 is the strongest genetic risk factor for Alzheimer’s. Studying this how this gene works, Dr. Kizil and colleagues found that inflammation triggers production of the protein fibronectin, which damages the blood–brain barrier (BBB).While it was known that damage to the BBB is an early feature of Alzheimers, this research is the first to explain the biological mechanism for this. Support cells produce fibronectin in response to inflammation, which causes further inflammation and directly damages the BBB.What's Next? While APOE4 is an unpreventable genetic mutation, inflammation is modifiable. If care providers can identify and target the inflammation that causes the fibronectin response, this potentially could lead to a prevention strategy for Alzheimer’s disease, even in non-genetic cases.
@kill-bait.bsky.socialSep 18, 2026, 3:32 PM

Targeting Fibronectin Restores Blood-Brain Barrier Integrity in Alzheimer's Preclinical Models

🤖 IA: It's not clickbait ✅
👥 Users: It's not clickbait ✅

#alzheimers #bloodbrainbarrier #fibronectin

👇👇👇

@medchemexpress.bsky.socialSep 15, 2026, 9:00 AM

Could #fibronectin be a missing link between #APOE4 and BBB dysfunction in #Alzheimers disease? A new Nature Aging study identifies astrocyte-derived fibronectin (FN1) as a key mediator of APOE4-driven BBB dysfunction.
AD-related research tools from MedChemExpress: https://ow.ly/ftrS50ZNEtg