@abhishekgarglab.bsky.social 🌅 #Research #Alert
SERPINH1 derived from #cancer-associated #fibroblasts promotes epithelial-mesenchymal transition in clear cell renal cell #carcinoma
👉 Access here: www.nature.com/articles/s41...
@springernature.com #Genes & #Immunity
@lozanzi.bsky.social#WeekendRead! #EveryCellsIsAnImmuneCell! Sonnenberg, Chu, Zhou &co show @science.org that a population of gut #fibroblasts produce IGF1, dampening interferon-gamma #IFNg driven CXCL10 by ILC3s & reducing pDC recruitment, restraining gut inflammation in mouse models! This circuit is altered in #IBD!
@ruichaoliu.bsky.social3/ The illustration was first generated with ChatGPT, then reimagined by an artist.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
@stemcellsciencenews.comNew in @pnas.org! Researchers showed the critical role of CTGF+ cancer-associated #fibroblasts in pancreatic ductal #adenocarcinoma progression and position QX03-46 as a promising therapeutic candidate for targeting the fibrotic #tumor microenvironment.
Read the paper here: https://bit.ly/4rmuYnd
@imag-ic.bsky.social#FluorescenceFriday Spiderweb-like structure by skin #fibroblasts at IMAG’IC. 🟢 #Collagen I immunofluo + 🟣 #SHG fibrillar collagen, #multiphoton microscopy
Valérie A. @crm-myologie.bsky.social
@institutcochin.bsky.social
@upcite.bsky.social
@inserm.fr
@cnrs.fr
@nicolasavilalab.bsky.socialTo close the loop, boosting mitochondrial activity in myofibers increased CSF1 availability by #expanding CSF1+ #fibroblasts—not by increasing Csf1 expression per cell. Blocking CSF1-CSF1R signaling depleted macrophages and caused muscle mitochondrial activity to collapse.
@nicolasavilalab.bsky.socialWho produces CSF1 and links tissue mitochondrial activity to macrophage numbersâť“ Multiple approaches pointed to #fibroblasts: they showed the highest CSF1 expression and closely associated with macrophages, suggesting they form the homeostatic macrophage nichei in muscles
@newsen.bsky.socialFibroBiologics Secures New Patent for Revolutionary Wound Healing Treatment Using Fibroblasts #USA #Houston #Wound_Healing #Fibroblasts #FibroBiologics