Happy I could contribute to this project in a small way. If you're interested in #ESR1 / #EstrogenReceptor (ER) in breast cancer, give it a read! #brca #breastcancer

ESR1-mutant #breastcancers show increased mutational burden, proliferation, and enhanced mTORC1 signaling, linking ER activity to tumor aggressiveness. A multi-omic signature predicts #ESR1 mutations and identifies patients at higher risk of recurrence and poor outcomes.

doi.org/10.1038/s420...

🎯#FDA approves #camizestrant (#Etcamah, AstraZeneca) + a CDK4/6 inhibitor for #ESR1-mutated HR+/HER2− advanced or metastatic breast cancer, using ctDNA to detect emerging resistance and guide a targeted treatment switch.

#FDAApproval #BreastCancer #ctDNA #PrecisionMedicine #Oncology