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@epithelial-barrier.bsky.socialSep 24, 2026, 7:15 AM

Li, S., Tian, W., Zheng, Y. et al. Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases. Clinic Rev Allerg Immunol 69, 74 (2026).

👉 link.springer.com/article/10.1...

epithelialbarriertheory.com

#EpithelialBarrierTheory

Climate change exacerbates extreme temperature events, which pose a growing global threat to human health, especially disturbing the immune system and increasing the incidence of immune-related diseases. This review synthesizes the multifaceted links between extreme temperatures and human immune system. Extreme temperatures could activate the neuroendocrine system, trigger the release of cytokines, regulate heat shock proteins (HSPs) and induce epigenetic modifications. The epithelial barrier dysfunction and gut microbiota dysbiosis are involved in the association between extreme temperature and immune system. These immune perturbations increase the risk of allergic diseases, autoimmune disorders and infectious diseases, disproportionately affecting children, elderly, patients with chronic diseases and people living in low-income and geographically vulnerable areas. Noting limitations like insufficient focus on vulnerable groups and static models, this review highlights the urgency of addressing climate-temperature-immunity interactions to guide climate-resilient public health strategies.
@epithelial-barrier.bsky.socialSep 10, 2026, 7:42 PM

R. Jiménez-Saiz, S. Iborra, C. Blanco, et al., “ Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases,” 👉 doi.org/10.1111/all.70512.

#EpithelialBarrier #Type2Immunity #Allergy #Immunology #Microbiome

epithelialbarriertheory.com

#EpithelialBarrierTheory

Type 2 (T2) immunity is best known for its role in allergy and eosinophilic inflammation, but it also has important functions in tissue protection, repair, and homeostasis. At epithelial barriers, T2 responses are closely shaped by interactions between epithelial cells, the immune system, and the microbiome. Barrier damage and microbial dysbiosis are increasingly recognized across a growing spectrum of T2 diseases. As biologics targeting IL-4, IL-5, IL-13, IL-31, TSLP, and IgE transform treatment, an important question emerges: what are the long-term consequences of suppressing pathways that also contribute to tissue protection and repair?
@epithelial-barrier.bsky.socialSep 8, 2026, 9:45 PM

Zhao, B., Babayev, H., et al., Monosodium Glutamate Induces Cellular Stress, Endoplasmic Reticulum Stress, Mitochondrial Dysfunction, and Cell Death in Intestinal Epithelial Cells. 👉 doi.org/10.1111/all.70007

epithelialbarriertheory.com

#EpithelialBarrierTheory @allergy-eaaci.bsky.social

@epithelial-barrier.bsky.socialSep 5, 2026, 3:42 PM

Serhan, N., Abdullah, N.S., Gheziel, N. et al. Maternal stress triggers early-life eczema through fetal mast cell programming. Nature 646, 161–170 (2025).

Read the article here: nature.com/articles/s41586-025-09419-8

epithelialbarriertheory.com
#EpithelialBarrierTheory