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@epithelial-barrier.bsky.social Sep 10, 2026, 7:42 PM

R. Jiménez-Saiz, S. Iborra, C. Blanco, et al., “ Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases,” 👉 doi.org/10.1111/all.70512.

#EpithelialBarrier #Type2Immunity #Allergy #Immunology #Microbiome

epithelialbarriertheory.com

#EpithelialBarrierTheory

Type 2 (T2) immunity is best known for its role in allergy and eosinophilic inflammation, but it also has important functions in tissue protection, repair, and homeostasis.

At epithelial barriers, T2 responses are closely shaped by interactions between epithelial cells, the immune system, and the microbiome. Barrier damage and microbial dysbiosis are increasingly recognized across a growing spectrum of T2 diseases.

As biologics targeting IL-4, IL-5, IL-13, IL-31, TSLP, and IgE transform treatment, an important question emerges: what are the long-term consequences of suppressing pathways that also contribute to tissue protection and repair?

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