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@jamanetworkopen.com Oct 9, 2026, 3:15 PM

📈 In middle-aged adults with #Obesity, 4 weeks of urolithin A did not improve peripheral #EndothelialFunction vs placebo, but task-evoked #CerebrovascularFunction responses increased. ja.ma/4hWXM1A

JAMA Network Open RCT on Urolithin A for middle-aged adults with obesity (50 participants: 37F, 13M). 25 received Urolithin A, 25 placebo for 4 weeks. Findings show no statistically significant difference in brachial artery flow-mediated dilation; a scatter plot illustrates minimal change from baseline for both groups.

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