Sulfatase Heart #Zebrafish🐟

SULF1 ⏫TGFβ signal in injured-regenerating🫀
Via shedding HSPG

SULF1-deficient🐟 💘
⏬pSMAD3+ epicardial cells
⏬PCNA+ cardiomyocytes
⏫Myofibroblasts & fibrosis
⏫L-plastin+ Leukocytes➡️pro-inflamm Mφ

@rmarinjuez.bsky.social #EmboRep 2026
link.springer.com/article/10.1...