Epigenetics Update - Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma www.nature.com/articles/s41...
Erik P. Sulman and janeskok.bsky.social in Nat Commun

Epigenetics Update - Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma www.nature.com/articles/s41...
Erik P. Sulman and janeskok.bsky.social in Nat Commun
Researchers have developed a molecule that boosts cells’ ability to repair oxidative #DNADamage. In human liver cells and mice, it reduced liver injury caused by paracetamol toxicity and improved survival. Published in Advanced Science. #LiverResearch 🧪
🔆 #PaperSpotlight:
A new #Review was published on August 31, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🎥 #AgingShort:
Abstract #Video about the #Review, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔆 #PaperSpotlight:
"The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework"
#PressRelease ⬇️
https://bit.ly/4ycmdPi
#Aging #DNADamage #Senescence #OA #PeerReviewed #Press #DNA #Publishing
✨NAR Molecular Medicine✨
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social