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@jlbjournal.bsky.socialOct 9, 2026, 7:17 PM

Sun-Hwa Kim and colleagues report a metabolite-mediated feedback circuit linking #Neutrophils, commensal #Bacteria, and #DendriticCells in the intestinal mucosa

@discovimmunol.bsky.socialSep 30, 2026, 11:00 AM

🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation.

👉 vist.ly/5kesn

#Immunology #DendriticCells #CellMetabolism #OpenAccess

Diagram showing reduced DC and T cell activation with eIF5a and spermidine.
@alicefrolov.bsky.socialSep 28, 2026, 5:31 PM

Weakening of the DC–T Cell Immunological Synapse with Age

I am sharing a data visualization from ongoing conceptual work on age-associated remodeling.

#Immunosenescence #DendriticCells #ImmunologicalSynapse #TCellActivation #Costimulation #LigandReceptorInteractions

Weakening of the DC–T Cell Immunological Synapse with Age I am sharing a data visualization from ongoing conceptual work on age-associated remodeling of dendritic cell–T cell communication at the immunological synapse. The figure, "Weakening of the DC–T Cell Immunological Synapse with Age," is rendered as a curved bipartite flow map (ligand-receptor arc diagram), with dendritic cell ligands on the left axis and cognate T cell receptors on the right. Arc width and opacity encode simulated signaling strength, contrasted between young and aged tissue states. I want to be explicit that the underlying values are simulated. They are not drawn from a single empirical dataset but are parameterized to reproduce trends consistently reported in the immunosenescence literature. The visualization is intended as a mechanistic scaffold for discussion rather than as primary evidence. The mapped interactions include the peptide-MHC Class II to TCR-CD3 axis, the costimulatory CD80/CD86 to CD28 pair, CD40 to CD40L feedback, ICAM-1 to LFA-1 adhesion, and inhibitory PD-L1 to PD-1 signaling. In the aged condition, the diagram depicts attenuated pMHCII–TCR and CD80/86–CD28 arc weights, consistent with reduced antigen presentation efficiency and diminished costimulatory competence in aged DCs. Concurrently, the PD-L1–PD-1 arc is broadened, reflecting the shift toward inhibitory tone described in exhausted and senescent T cell compartments. ICAM-1–LFA-1 attenuation is included to represent reported deficits in synapse stability and conjugate formation. The composite effect illustrated here is a quantitative and qualitative degradation of productive synaptic signaling, favoring incomplete T cell priming and skewed activation thresholds. I would welcome critique on the ligand-receptor pair selection and on plausible weighting priors that could later be constrained with single-cell interactome or spatial proteomic data.
@gmj-georgia.bsky.socialSep 24, 2026, 9:26 PM

New laboratory research reveals creatine may strengthen cancer-fighting immune pathways by energizing dendritic cells that activate killer T c… #Cancerimmunotherapy #Creatine #Dendriticcells #Immunemetabolism #Translationalresearch #Cancerimmunotherapy #Creatine #Dendriticcells #Immunemetabolis…