How can virtual reality-based cognitive assessment games (VR-CAG) support cognitive markers for hippocampal vulnerability?

This new review in #DADM outlines 29 studies that identify 3 neural systems underlying VR-CAG

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#DADM Key Details:

🧠920 dementia-free individuals in Northern Manhattan
🧠CVH defined using eight behavioral and clinical metrics
🧠60% female & 65% Hispanic

New in #DADM: Cardiovascular health (CVH) and incident dementia in The American Heart Association's Life's Essential 8 (LE8) study

⬇️ CVH was associated with dementia risk and supported the CVH metrics were valid in diverse populations

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

In the modeled two-step pathway, digital cognitive assessment enriched the population undergoing biomarker testing before pTau217 measurement

This ⬆️pre-test positivity from 30% to 66.6% and improved positive predictive value of pTau217 from 81.7% to 95.3% #DADM

New research in #DADM highlight @altoida NeuroMarker, a 10-minute self-administered digital cognitive assessment.

Findings support individuals identified as cognitively impaired were more likely to have elevated plasma pTau217🩸

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

How do frontotemporal dementia (FTD) symptoms present in Hispanic populations?

New research in #DADM shows Hispanic participants presented with more movement-related symptoms and advanced cognitive impairment diagnosis

Full Study: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#DADM Publication Key Details:
🧠148 cases were evaluated
🧠FTLD-TDP type A cases were younger at onset and death, had shorter disease duration
🧠LATE-NC cases were older and sporadic
🧠FTLD type A and LATE-NC could be differentiated with >95% confidence

New in #DADM!

Key differences in clinicopathological presentation of frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) and limbic-predominant age-related TDP-43 encephalopathy (LATE-NC)

Learn more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#DADM Call For Paper Deadline Approaching!📢

Topic: Novel multi-omic Diagnostic and Analytical approaches for ADRD

⏰Submission Deadline: November 30, 2026

Guest Editors: Carlos Cruchaga, Victoria Fernandez

Full CFP: alz-journals.onlinelibrary.wiley.com/hub/journal/...

#DADM Call for Papers📢

Don't forget to submit to this Special Issue!

2nd Edition: Real-World Evidence on Amyloid-Targeting Treatments: Early Data on Clinical Implementation, Safety, and Efficacy

⏰Deadline: Oct. 31, 2026

alz-journals.onlinelibrary.wiley.com/hub/journal/...