#WEHI researchers developed #Partita, a high-density mouse genome-wide #CRISPRa library (263,460 sgRNAs), mapping #cancer dependencies, Irx5-driven venetoclax resistance, and in vivo MYC-synergistic oncogenes (Runx2/Runx3/Csf1r). 🐭🤖 #ScienceAdvances2026 #DrugResistance #InVivoScreening

Sun Yat-sen University researchers established the first plant cell-based #CRISPRa screen, identifying #OsTV1—a papillae-specific receptor kinase that interacts with silicon transporter OsSIET4 to drive broad-spectrum fungal resistance in #rice without yield penalties. 🌾🤖