@epigentek.bsky.socialWhat can cfDNA tell us that sequence alone cannot?
Methylation patterns, fragment length and end motifs, and nucleosome-associated fragmentation can provide complementary signals for tissue-of-origin, cell-type, and chromatin-accessibility inference.
@yalecancer.bsky.socialDr. Ignaty Leshchiner and colleagues analyzed #cfDNA blood samples from 12,000+ patients with metastatic #breastcancer & found serial cfDNA testing can detect newly-emerging resistance mutations before clinical progression.
medicine.yale.edu/cancer/publi...
@yalecbb.bsky.social