16. #CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination - Brown et al. doi.org/10.1093/narc.... Addresses the session's cell-cycle/replication repair interface by connecting cyclin-CDK2 activity to HR repair of collapsed forks. 17/18

CDK2, part of the machinery driving cell division, is often hyperactive in cancer.

A new study from Drs. Wucherpfennig and Sicinski at @danafarber.bsky.social identifies #CDK2 inhibition as a potential clinical target.

🔬 Abstract: https://bit.ly/4A9K5nU
🗞️ Press release: https://bit.ly/4A9GpTd