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@sigtrans-sttt.bsky.socialOct 9, 2026, 3:45 PM

How can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments?

This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics
@sigtrans-sttt.bsky.socialOct 9, 2026, 12:45 PM

This review links genomic and #Epigenetic changes, metabolic adaptation, immune escape, and therapy-driven selection to emerging evolution-guided strategies for #PrecisionOncology. @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets
@sigtrans-sttt.bsky.socialOct 9, 2026, 6:30 AM

ENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

Alpha-enolase influences ATP pool of cytoplasm and lactate homeostasis by regulating glycolysis in gastric cancer