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@bvsspa.bsky.socialSep 18, 2026, 6:12 AM

šŸ‘‰ Disponible en #risalud hdl.handle.net/10668/30228

#BVSSPA #OnychocoloneA #CancerStemCells

@wayne003.bsky.socialSep 16, 2026, 8:04 AM

Review of PRX5 in cancer stem cells šŸ“Š Low ROS sustain CSC self-renewal, drug resistance. šŸ”¬ PRX5 redox balance protects STAT3 from inactivation. šŸ’” Target: destabilize STAT3, reduce CSC self-renewal. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #PRX5 #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@wayne002.bsky.socialSep 16, 2026, 8:04 AM

Review of PRX5 in cancer stem cells šŸ“Š Low ROS sustain CSC self-renewal, drug resistance. šŸ”¬ PRX5 redox balance protects STAT3 from inactivation. šŸ’” Target: destabilize STAT3, reduce CSC self-renewal. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #PRX5 #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@w77576780.bsky.socialSep 16, 2026, 8:04 AM

Review of PRX5 in cancer stem cells šŸ“Š Low ROS sustain CSC self-renewal, drug resistance. šŸ”¬ PRX5 redox balance protects STAT3 from inactivation. šŸ’” Target: destabilize STAT3, reduce CSC self-renewal. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #PRX5 #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@wayne003.bsky.socialSep 15, 2026, 9:32 AM

Review of PRX5 in cancer stem cells šŸ“Š CSCs keep ROS low to self-renew and resist drugs. šŸ§¬ PRX5 redox balance shields STAT3 from degradation. šŸ’” Targetable: prognostic biomarker, therapy target. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@wayne002.bsky.socialSep 15, 2026, 9:31 AM

Review of PRX5 in cancer stem cells šŸ“Š CSCs keep ROS low to self-renew and resist drugs. šŸ§¬ PRX5 redox balance shields STAT3 from degradation. šŸ’” Targetable: prognostic biomarker, therapy target. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@w77576780.bsky.socialSep 15, 2026, 9:31 AM

Review of PRX5 in cancer stem cells šŸ“Š CSCs keep ROS low to self-renew and resist drugs. šŸ§¬ PRX5 redox balance shields STAT3 from degradation. šŸ’” Targetable: prognostic biomarker, therapy target. DOI: https://doi.org/10.32604/biocell.2026.079386 #CancerStemCells #STAT3

Schematic representation of the human PRX family, highlighting isoform classification, catalytic mechanisms, and subcellular localization. Mammalian PRXs are categorized into typical 2-Cys (PRX1ā€“4), atypical 2-Cys (PRX5), and 1-Cys (PRX6) subgroups based on the number and positioning of catalytic cysteine residues. Unlike typical 2-Cys PRXs, which form intermolecular disulfide bonds, PRX5 utilizes an intramolecular disulfide bond, conferring distinct structural and functional properties. Abbreviations: SO 2 H, sulfinic acid (hyperoxidized inactive form); MTS, mitochondrial targeting sequence; PTS1, peroxisomal targeting signal 1 ( Fig. 1 is our original work and was prepared using Microsoft PowerPoint 2021).
@alicefrolov.bsky.socialSep 10, 2026, 5:07 PM

Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure.

#CancerStemCells #TumorHeterogeneity #ClonalEvolution #MinimalResidualDisease #TumorPlasticity #DrugTolerantPersisters #SingleCellGenomics #PhylogeneticReconstruction

Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure. Figure: "Therapy reshapes clonal hierarchy via stem-like subclone selection" Subtitle: "Ranked clonal fraction of tumor subclones across treatment phases; stem-marked clones rise under selective pressure" The chart is a phylogenetic bump plot (Muller-style ranked clonal flow) tracking the relative clonal fraction of individual subclones across sequential treatment phases: baseline, on-treatment, minimal residual disease (MRD), and relapse. Each ribbon corresponds to a distinct subclone, with vertical band thickness encoding clonal fraction and vertical ordering encoding rank. Subclones carrying stem-associated marker states (e.g., high ALDH activity, CD133/CD44 enrichment, quiescence-linked transcriptional programs) are highlighted to distinguish them from bulk proliferative lineages. The illustrated trajectory recapitulates a well-documented pattern: cytotoxic selection preferentially depletes proliferative, differentiation-committed subclones while sparing slow-cycling, stem-marked populations. During the MRD window, stem-like ribbons ascend in rank despite overall tumor contraction, consistent with therapy-tolerant persister states buffered by quiescence, enhanced drug efflux, and reinforced self-renewal signaling (WNT, NOTCH, Hedgehog). At relapse, these ascended subclones seed the reconstituted hierarchy, producing a repopulated tumor with an altered clonal architecture rather than a faithful reconstruction of the baseline composition. I want to emphasize that the underlying data here are simulated. The intent is to render a literature-grounded trend in an interpretable topological format, not to present empirical measurements. The parameterization draws on reported CSC plasticity and selection dynamics, but ribbon values are synthetic.