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@jimmunol.bsky.social Sep 11, 2026, 6:20 PM

In a #BriefReview authors discuss the role of lysosomes in immune cells and their potential for developing targeted therapeutic strategies and for enhancing the safety and efficacy of novel biological entities (NBEs). Find the full article in The JI: https://ow.ly/Aofs50ZLyaL.

Extracellular protein processing and presentation in the endocytic pathway. Antigen-presenting cells engulf extracellular proteins via endocytosis mechanisms, encapsulating them in early endosome vesicles. After undergoing a maturation step, newly late endosomes can merge with lysosomes into intermediate structures, known as endolysosomes, where antigen processing occurs. The newly generated peptides are loaded onto the MHCII molecules and presented on the APC’s surface membrane. The recognition of MHCII-peptide complexes promotes the activation, differentiation, and proliferation of CD4+ Th cells.

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