Vonk et al. report that an AI system detects clinically recognizable speech errors from a brief reading task, correlating with expert motor speech ratings and distinguishing nonfluent from logopenic primary progressive aphasia.

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Leo et al. report that serum cell-free mRNA distinguishes adult-onset spinal muscular atrophy from controls and shifts with risdiplam, supporting it as a biomarker to monitor treatment and reveal residual pathology.

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Using meta-analysis of differential gene expression datasets and clinical validation, de Oliveira et al. report that glial fibrillary acidic protein is a candidate biomarker for spinal muscular atrophy.

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Wang et al. found altered EEG brain-state dynamics in Parkinson’s disease with mild cognitive impairment, with state transitions correlating with cognitive scores and potentially serving as biomarkers of cognitive decline.

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Zhou et al. report that adolescents with ADHD segment ongoing experience less sensitively: EEG reveals neural overstabilization before and reduced re-engagement after event transitions, which might restrict adaptive updating.

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D’Amelio et al. report that, in a triple-transgenic Alzheimer’s disease mouse model, susceptibility to retroactive interference reveals early, sex-specific memory fragility before overt deficits appear.

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Fujita et al. report that serial MRI up to 15 years reveals marked individual differences in brain volume loss among cognitively normal adults, including rapid-atrophy and atrophy-resistant phenotypes linked to modifiable lifestyle factors.

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What Kafka’s Metamorphosis reveals about consciousness without communication? In his essay, Demas uses Gregor Samsa’s example to explore the limits of observable behaviour as a measure of consciousness.

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Orlando et al. show that heart rate variability is preserved in people with Parkinson’s disease receiving an acute dose of atomoxetine, supporting a safe cardiovascular profile for the drug.

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Sintini et al. report that MRI and 18F-FDG PET principal components diagnostic outperformed tau-PET, with the highest sensitivity for the semantic variant of primary progressive aphasia and progressive supranuclear palsy.

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Leveraro et al. report that patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder show altered functional brain organization despite preserved cognition.

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Conti et al. report that impaired awareness of visual hallucinations in Lewy body disease involves reduced resting-state connectivity between right visual association and prediction-error systems.

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Norouzi et al. studied periodic and aperiodic resting-state features in Parkinson’s patients across six EEG and MEG datasets, finding elevated alpha power, slower alpha peak frequency, and higher aperiodic offset and exponent.

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Keute et al. report that verbal and visuospatial working memory outcomes after deep brain stimulation in Parkinson’s disease were linked to baseline cortical activity and stimulation-related spectral changes.

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Meron et al. report reduced neural responsivity to startling stimuli in post-ictal larval zebrafish, alongside increased receptor density at inhibitory glycinergic synapses. Disrupting these receptors restores responsivity.

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Ringshaw et al. demonstrated that antenatal maternal anaemia may impact child brain structure as early as infancy, with detectable effects from 12 months of age, using ultra-low-field MRI.

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Meet Dr Roisin McMackin, an Assistant Professor of Physiology at Trinity College Dublin 👋

She leads a research team studying neural network dysfunction in health and neurodegenerative diseases, focusing on amyotrophic lateral sclerosis and Huntington’s disease.

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Laginha et al. report consistently reduced plasma and CSF prion protein (PrP) in D178N carriers, supporting plasma PrP as a promising pharmacodynamic biomarker for PrP-lowering trials for prion diseases.

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Using clinically acquired brain MRI from 442 individuals with focal epilepsy, Ndagijimana et al. demonstrate that hippocampal volumetric asymmetry is a robust marker of pathologically confirmed hippocampal sclerosis.

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Unlu Kobya et al. show that neuron-derived orphan receptor 1 is reduced in the motor cortex of multiple sclerosis and is associated with increased inflammation and ageing.

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