Researchers developed the CONCORD platform combining conjugation and base editing to write data directly into living cells. The system successfully encoded 45,689 bits of information, including artifacts from NASA missions.

#SyntheticBiology #DNAEncoding #BaseEditing

Seung Hwan Lee’s team developed dBhCas12b-ABE, a Cas12b adenine base editor targeting T-rich PAMs that suppresses indels to 0–0.04% and offers tunable editing windows. 🧬🤖 #CRISPR #BaseEditing #Cas12b #MolecularTherapy #GeneEditing #ChungAngUniversity

#UCBerkeley researchers developed PERCEPT, using self-immolative reduction-sensitive linkers to decorate #CRISPR #RNPs with PEG, escape peptides, and targeting ligands for targeted in vivo editing across brain, retina, muscle, and lung tissues. 🧠🤖 #GeneEditing #bioRxiv2026 #PERCEPT #BaseEditing

🧬 One wrong letter in one gene. That's the whole disease.

HMSN-P, found in Okinawan families in 1983, comes down to a single DNA typo. A Japan-led team just corrected it in mice and patient cells — without cutting the DNA.

#BaseEditing #HMSNP #Okinawa #CiRA #GeneEditing

Synergistic optimization nearly triples cytosine base-editing efficiency in potato and enables efficient dual editing of StALS1 and StALS2 #PotatoEditing #BaseEditing #PrecisionBreeding @academic.oup.com
Details: doi.org/10.1093/hr/u...

The UK has approved its first precision-bred crop — a vitamin D–biofortified tomato from the #JohnInnesCentre delivering roughly the vitamin D of 2 eggs per fruit — while #WiMi supports #knockout, #baseediting, and #knock-in transformation across 30+ crop species and genetic backgrounds.

Mohankumar et al. demonstrated that #truncatinggRNAs to 15–19 nt narrows the #baseediting window to suppress bystander mutations across ABE and CBE platforms, with 17 nt guides optimizing target precision during transient delivery in primary CD34+ HSPCs. 🩸🤖 #BystanderEditing #HSPCs #GeneTherapy

IPK Gatersleben researchers established the first base editing platform in barley, targeting HvEIF4E to create novel BE alleles 7 & 8 that confer robust BaMMV resistance without sacrificing grain yield. 🌾🤖 #BarleyGenomics #BaseEditing #bioRxiv2026 #PlantBiotech #CropProtection #EIF4E