In @jhumimmunity.org, Mogensen et al. investigated the heredity of IFN-I #autoantibodies in adults in a large Danish twin cohort of 1,318 twin pairs. Overall, the data do not support a strong familial aggregation, as reflected by a low concordance rate for IFN-I auto-Abs. rupress.org/jhi/article/...

Clemmensen, Mørk, Mogensen et al. investigated the heredity of IFN-I #autoantibodies in adults in a large Danish twin cohort of 1,318 twin pairs. Overall, the data do not support a strong familial aggregation, as reflected by a low concordance rate for IFN-I auto-Abs. rupress.org/jhi/article/...

Sbruzzi, Vianna et al. show that neutralizing #autoantibodies against type I IFNs are more frequent in severe, critical, and fatal #COVID19 cases in southern Brazil, highlighting their role in disease severity and extending global evidence to a Latin American population. rupress.org/jhi/article/...

In @jhumimmunity.org, Sbruzzi et al show that neutralizing #autoantibodies against type I IFNs are more frequent in severe, critical & fatal #COVID19 cases in southern Brazil, highlighting their role in disease severity and extending global evidence to a LatAm population. doi.org/10.70962/jhi...

#HowITreat in @jhumimmunity.org from Joseph Oved: In primary immune regulatory diseases and inflammatory disorders, targeted immune modulation may control symptoms for some, but alloHCT remains the only cure for many patients. rupress.org/jhi/article/...

#Infections #autoantibodies

#HowITreat from Joseph Oved: In primary immune regulatory diseases and inflammatory disorders, targeted immune modulation may control symptoms for some, but alloHCT remains the only cure for many patients. rupress.org/jhi/article/...

#Infections #autoantibodies

#Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults. By Julie Jensen, Morten Kelder Skouboe, Adrian Gervais, Shen-Ying Zhang, Søren Paludan, Aurelie Cobat, Jean-Laurent Casanova, Trine Mogensen @au.dk and colleagues: rupress.org/jem/article/...

Adults with single islet #autoantibodies who develop diabetes don’t all follow same path; some need early #insulin, others don't. 2026 #EASD/#EFSD Rising Star Nicholas Thomas’ research investigates who’s at greatest risk of needing insulin & how to predict this link.springer.com/article/10.1...

Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults with HSV encephalitis (5%) compared with the general population rupress.org/jem/article/...

In @jem.org, Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults w/ HSV encephalitis (5%) compared w/ the general population rupress.org/jem/article/...

High prevalence of #autoantibodies neutralizing type I IFNs in Japanese patients with #hepatitis C. New study from Maki Taniguchi, Satoshi Okada and colleagues (Hiroshima University):
rupress.org/jhi/article/...

#Autoimmunity #Infections #InbornErrorsOfImmunity

In Life Science Daily News, Exagen CSO Michael Mahler, PhD, explains how deep B‑cell depletion and IgG blockade are redefining autoantibodies—from diagnostic clues to signals of treatment response and immune reconstitution. Questions? Comment or contact Michael. #Autoantibodies #BCellTherapy

Taniguchi et al. find the prevalence of #autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ #hepatitis C (2.7%) than in age-matched healthy controls (0.7%), and is even higher in those treated w/ IFN-α than in untreated individuals. rupress.org/jhi/article/...

Prevalence of neutralizing #autoantibodies against type I #interferon in #dengue patients. New study from Mengtian Yang, Yixin Liao, Feng Li, Haisheng Yu (Guangzhou Medical University), Yun Ling (Fudan University) and colleagues:
rupress.org/jhi/article/...

#Infections

Research Article

Autoantibodies and Relapse of Systemic Sclerosis After Autologous Hematopoietic Cell Transplantation

📖 www.jrheum.org/cgi/content/...
@ucalgary.bsky.social

#Autoantibodies #AutologousTransplant #SystemicSclerosis

Editorial

Predicting Relapse After Autologous Hematopoietic Cell Transplantation in Systemic Sclerosis: What Autoantibodies Can and Cannot Tell Us

📖 doi.org/10.3899/jrhe...
@raffaellagreco.bsky.social

#Autoantibodies #AutologousTransplant #SystemicSclerosis