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@embomolmed.orgSep 28, 2026, 6:54 PM

Endothelial #SLC25A13 links #glutamine metabolism to #angiogenesis

By A. Subramanian, P. Carmeliet & colleagues at KU Leuven, Leuven Cancer Institute (LKI)

🗞️ doi.org/10.1038/s44321-026-00524-3

@haoyin.bsky.socialSep 23, 2026, 12:14 PM

#Angiogenesis
#Zebrafish

FoxH1 (schmalspur/sur) negatively modulates flk1 gene expression and vascular formation in zebrafish🐟

Antagonizing vascular expansion induced by SMAD2 morpholino

Always nice to revisit some classical piece😀

@devbiol.bsky.social 2007
www.sciencedirect.com/science/arti...

@cancers-mdpi.bsky.socialSep 23, 2026, 8:38 AM

📣Check out some highly cited #SpecialIssues in 2025 related to our section "Tumor Microenvironment"

Explore here🔎 www.mdpi.com/about/announ...

#TumorMicroenvironment #metastasis #angiogenesis #IntercellularCommunication @mdpiopenaccess.bsky.social

@stemcellsciencenews.comSep 15, 2026, 5:09 PM

Dr. Dissanayaka and researchers established mitochondrial transfer as a vital metabolic lifeline that prevents endothelial cell collapse and drives #DentalPulpStemCell-supported #angiogenesis in the hypoxic pulp during the vulnerable window of pulpal restoration. 🦷

🔎 https://bit.ly/3SZ3rLY

@alicefrolov.bsky.socialSep 14, 2026, 5:03 PM

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response.

#TumorHypoxia #HIF1alpha #TumorMicroenvironment #Angiogenesis #OxygenSensing #VEGF #ComputationalOncology #CancerMetabolism

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response. Figure: "Oxygen tension collapse drives coordinated hypoxia-angiogenesis program across the tumor radius" Subtitle: "Simulated intratumoral pO₂ gradient from vessel wall to necrotic core with HIF-target activation" The figure uses a horizon-style stacked area representation (layered oxygen-gradient contour strip) to render pO₂ as a function of radial distance from the perfused vessel wall toward the necrotic core. Each contour band encodes a discrete oxygen tension interval, with marker overlays indicating the activation thresholds of canonical HIF-1α target loci. I want to emphasize that the underlying data are simulated; the parameterization reflects diffusion-limited oxygen distributions consistent with published Krogh-cylinder estimates and the well-characterized ~100–200 µm diffusion limit. The central observation is the coordinated character of the transcriptional program along the radial axis. Proximal to the vessel wall, pO₂ remains above the threshold for prolyl hydroxylase domain (PHD/EGLN) activity, sustaining VHL-mediated HIF-1α degradation. As oxygen tension declines toward the intermediate perinecrotic zone, PHD activity becomes substrate-limited, HIF-1α escapes hydroxylation and proteasomal turnover, and it accumulates to drive HRE-dependent transcription. The marker overlays illustrate the staggered engagement of glycolytic effectors (SLC2A1, LDHA), pH-regulatory targets (CA9), and pro-angiogenic signaling (VEGFA) as the gradient steepens. The horizon-strip format was chosen deliberately to compress the steep radial pO₂ decay into a legible vertical encoding while preserving the coincidence between tension thresholds and target activation.
@stemcellsciencenews.comSep 7, 2026, 3:05 PM

This @cp-cellreports.bsky.social study uncovers a metabolic-epigenetic pathway that controls pathological #angiogenesis and nominates HDAC1 lactylation as a therapeutic target for #diabetic vascular complications.

🔗 https://bit.ly/4ic5gzk