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@allergy-eaaci.bsky.socialOct 8, 2026, 3:23 PM

Epithelial AhR–NKX3-1–Senescence Axis Drives Barrier Function and Inflammation in Allergic Rhinitis. First author: Xuan Yuan; corresponding authors: Zhihai Xie, Peisong Gao

👉 doi.org/10.1111/all.70489

Read more articles 👉 journalallergy.com/Rhinitis-Sinusitis-Upper-Airways
#Allergy_journal

This study investigates the role of aryl hydrocarbon receptor (AhR)-associated epithelial signaling and its contribution to #barrierdysfunction and allergic inflammation. Allergic rhinitis nasal epithelium exhibits increased AhR activity associated with senescence-related transcriptional programs and senescence-associated secretory phenotype (SASP) inflammatory signals. AhR deficiency and CC10-lineage-enriched p16 deletion attenuate epithelial senescence-associated programs, improve barrier integrity, and reduce Type 2 inflammation in vivo. NKX3-1 contributes to AhR-linked epithelial cell-cycle arrest and senescence-associated responses, while curcumin attenuates allergen-induced senescence-associated phenotypes.
@allergy-eaaci.bsky.socialOct 6, 2026, 4:11 PM

Open Access: Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis. First author: Takayoshi Komatsu-Fujii; corresponding authors: Ryota Asahina, Toshiaki Kogame, Kenji Kabashima

Read the article: doi.org/10.1111/all.70493

#Allergy_journal

This study demonstrates the role of OX40-OX40 signaling in pathogenic resident memory T cells (TRM) development using an oxazolone (OXA)-induced atopic dermatitis mouse model. Blockade of the OX40 pathway during the initial inflammatory phase suppressed TRM development and attenuated recall dermatitis. Human lesional atopic dermatitis skin showed a transcriptomic profile consistent with Th2/TRM-like features. These findings support further studies targeting the OX40-OX40L axis for the treatment of atopic dermatitis. Watch the video abstract prepared by the authors here: https://youtu.be/jRP3WgCdxVY Read more articles published in #Allergy on #atopicdermatis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease
@allergy-eaaci.bsky.socialOct 5, 2026, 3:29 PM

Open Access: Revisiting Platelet-Activating Factor in Asthma: An Exploratory Metabolomics Analysis of PAF C-18:1 and Type 2 Inflammation. Noeul Kang, Young Jin Pyung, Deog Kyeom Kim, Cheol-Heui Yun, Hyun Woo Lee

👉 doi.org/10.1111/all.70499

#Allergy_journal
journalallergy.com

Kang and Pyung et al., investigate type 2 inflammation mediated by various platelet-activating factors (PAF) in asthma and their association with achieving clinical remission. Only PAF C18:1 was found to be inversely associated with T2 inflammatory markers, in contrast to other PAF species detected in the plasma of asthma patients (alkyl-PAF and lyso-PAF). The authors suggest a structure-dependent relationship, whereby the double bond in PAF C18:1 may alter receptor binding or signaling.
@allergy-eaaci.bsky.socialSep 28, 2026, 3:47 PM

Open Access: Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants. First author: Ozge Ardicli; corresponding author: Willem van de Veen

Read the article here: doi.org/10.1111/all.70490

#Allergy_journal
journalallergy.com

This study shows that sodium dodecyl sulfate (SDS) and cocamidopropyl betaine (CAPB) directly impair esophageal epithelial barrier integrity in primary eosinophilic esophagitis (EoE)-derived models. SDS induces stronger inflammatory, oxidative stress, and keratinization responses than CAPB. Both surfactants promote epithelial remodeling and partial epithelial-mesenchymal transition (EMT), with CAPB showing a distinct extracellular matrix remodeling profile. Common surfactants in personal care products may act as environmental aggravating factors in eosinophilic esophagitis. Read more articles published in #Allergy on the #epithelialbarrier here: journalallergy.com/barrier-and-microbiota #Allergy_journal
@allergy-eaaci.bsky.socialSep 25, 2026, 2:53 PM

Impaired Clearance of Neutrophil Extracellular Traps in Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis. Corresponding author: Manao Kinoshita
👉 doi.org/10.1111/all.70507

Read more articles here: journalallergy.com/Drug-Insect-Anaphylaxis
#Allergy_journal

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, albeit life-threatening, adverse skin reaction to certain medications. Kinoshita et al. demonstrate that neutrophil extracellular trap (NET) degradation is impaired in SJS/TEN patients due to DNase 1 dysfunction, as patients were observed to exhibit significantly reduced DNase 1 activity and levels. The NET accumulation is further aggravated by inhibition of DNase 1 by G-actin released from necroptotic keratinocytes.
@allergy-eaaci.bsky.socialSep 24, 2026, 2:00 PM

A Strong Proposal for the Reasons of Pandemic Increase in Food Allergies

Could common food emulsifiers affect intestinal barrier integrity and IgE immune responses?

Read the open-access article: doi.org/10.1111/all.70473

@epithelial-barrier.bsky.social #Allergy_journal

journalallergy.com

In this new study, SIAF researchers and their international collaborators investigated soy lecithin and DATEM, two widely used emulsifiers found in processed foods, including some peanut butters. Using human gut-on-a-chip and adult stem cell-derived colon organoid-on-a-chip models, together with human immune cells and mouse models, the researchers found that both emulsifiers: 🔹 Disrupted intestinal epithelial barrier integrity 🔹 Activated pro-inflammatory pathways, including TNF and NF-κB signalling 🔹 Induced local and systemic inflammatory responses 🔹 Stimulated particularly IgEantibody responses Soy lecithin additionally induced oxidative stress and increased IgE levels in mice, while DATEM enhanced IL-4-induced IgE production in human peripheral blood mononuclear cells. These findings support the Epithelial Barrier Theory and highlight the need to consider barrier dysfunction and low-grade immune activation when evaluating the biological effects of commonly used food additives. Further studies are needed to determine their long-term effects in humans. Congratulations to the entire research team on this publication!
@allergy-eaaci.bsky.socialSep 23, 2026, 1:53 PM

Open Access: The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk. First author: Johanna M. Smeekens; corresponding author: Timothy P. Moran 👉 doi.org/10.1111/all.70501

#Allergy_journal

journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

With over 150 references, this review article provides an overview of the most important environmental exposures affecting food allergy. It includes a discussion of environmental food exposures via non-oral routes, microbial exposures, air pollution, industrial chemicals, and nutrition.
@allergy-eaaci.bsky.socialSep 18, 2026, 2:39 PM

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic #Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial. First author: Paula Virkkula
👉 doi.org/10.1111/all.70438

#Allergy_journal
Read more articles: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

Both Full and Limited FESS result in clinically meaningful relief of disease-specific health-related quality of life (HRQoL) and nasal breathing, effectively improving nasal symptoms and sleep disturbance in chronic rhinosinusitis with nasal polyps (#CRSwNP) patients. Clinically meaningful differences in decreases of SNOT-22 scores (22-item Sino-nasal Outcome Test) between the groups were not found at 12- and 24–month follow-up. Differences in improvement of anosmia, and decreases in polyp load were seen between the groups.
@allergy-eaaci.bsky.socialSep 14, 2026, 4:30 PM

K. Hosoki, A. Sur, A. Govindhan, et al., “T Cell-Intrinsic NEIL2 Restrains Th2 Allergic Inflammation by Regulating Chromatin Accessibility,” 👉 doi.org/10.1111/all.70500
#Allergy_journal
Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV
www.youtube.com/watch?v=5srA...

@allergy-eaaci.bsky.socialSep 13, 2026, 3:24 PM

Open access: Serum‐Proteomic Profiling Reveals Distinct #AtopicDermatitis Severity‐Linked Signatures. First author: Jag S. Lally; corresponding author: Anna De Benedetto
👉 doi.org/10.1111/all.70464

#Allergy_journal
More articles 👉 journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial-enriched severity footprint linked to lactate dehydrogenase (LDH)-associated tissue injury and Th2/Th22 inflammation. Machine learning identified a 9-protein biomarker signature that discriminated severity groups with high cross-validation accuracy (AUC = 0.989).
@allergy-eaaci.bsky.socialSep 12, 2026, 3:16 PM

M. J. Torres, C. Mayorga, E. J. Phillips, et al., “Nomenclature on Immune-Mediated Drug Reactions: An #EAACI Position Paper,” 👉 doi.org/10.1111/all.70480

#Allergy_journal
Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV

www.youtube.com/watch?v=1LdU...

@allergy-eaaci.bsky.socialSep 11, 2026, 4:18 PM

Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation—An #EAACI Position Paper
Corresponding author: Teodorikez-Wilfox Jimenez-Rodriguez

👉 doi.org/10.1111/all.70421

#Allergy_journal
Read more articles published in #Allergy here: journalallergy.com

With over 100 references, this #EAACI Position Paper reviews the potential of the honey bee venom allergen melittin as a potential candidate for the treatment of cancer. It provides mechanistic insights into its anti-tumor activity across various types of cancer, safety considerations, limitations and advancements.
@allergy-eaaci.bsky.socialSep 10, 2026, 4:13 PM

D. Ni, G. Pinget, B. Santner-Nanan, et al., “ #Biomarkers Predicting Sustained Unresponsiveness After Oral #Immunotherapy in the OPIA Trial,”
👉 doi.org/10.1111/all.70478

#Allergy_journal
Watch more videos👉 journalallergy.com and youtube.com/@Allergy-TV

www.youtube.com/watch?v=95lZ...

@allergy-eaaci.bsky.socialSep 9, 2026, 5:23 PM

Open Access: Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator-Initiated Study. First authors: Annika Gutsche, Weronika Grabowska; corresponding author: Martin Metz

👉 doi.org/10.1111/all.70454

#Allergy_journal

This study evaluates the effectiveness and safety of #dupilumab, an IL-4Rα inhibitor, for the treatment of cholinergic urticaria (ChoIU), a rare condition manifested as pruritic wheals triggered by sweating and increases in body temperature. In a phase 2 randomized, double-blind trial of 42 adults with ChoIU, no significant difference was observed between patients treated with dupilumab and those treated with placebo at weeks 16 and 32. #Allergy_journal Read more articles published in #Allergy on #urticaria here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease
@allergy-eaaci.bsky.socialSep 8, 2026, 5:11 PM

T. Komatsu-Fujii, R. Asahina, T. Hasegawa, et al., “ Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in #AtopicDermatitis,” 👉 doi.org/10.1111/all.70493

#Allergy_journal
Watch more videos 👉 journalallergy.com and youtube.com/@Allergy-TV

www.youtube.com/watch?v=jRP3...

@allergy-eaaci.bsky.socialSep 6, 2026, 4:20 PM

Effect of Abrocitinib on the Skin Microbiome in Patients with Moderate‐to‐Severe Atopic Dermatitis. First author: Madeline Kim; corresponding author: Emma Guttman-Yassky

👉 doi.org/10.1111/all.70467
Watch the video abstract here: youtube.com/watch?v=03MspazqW0E

#Allergy_journal

Atopic dermatitis (AD) is characterized by microbial dysbiosis. This study aimed to evaluate the effects of abrocitinib, a JAK1-selective inhibitor, on the skin microbiome and its potential associations with clinical outcomes in patients with AD. Abrocitinib treatment was associated with increased skin microbial diversity and decreased Staphylococcus aureus burden over 12 weeks that corresponded with efficacy improvements. %BSA, percentage of body surface affected; AD, atopic dermatitis; EASI, Eczema Area and Severity Index; FCH, fold change; IGA, Investigator's Global Assessment; Jak1, Janus kinase 1; PP-NRS, Peak Pruritus Numerical Rating Scale. Read more articles published in #Allergy here: journalallergy.com/
@allergy-eaaci.bsky.socialSep 5, 2026, 3:29 PM

Simultaneous Dual Type 2 Biologic Therapy Improves Sinonasal Outcomes in Selected Patients With Chronic Rhinosinusitis With Nasal Polyps. Corresponding author: Friederike Bärhold

Read the article here: doi.org/10.1111/all.70452

#Allergy_journal