Why do SGLT2 inhibitors protect heart and kidneys? 🫀
In @natrevneph.nature.com, we proposed that the body activates an aestivation-like program, shifting energy metabolism to conserve water and prevent glycosuria-driven dehydration. #aestivation still active in humans? #MedSky
rdcu.be/75K79DdbK1Aa

Over 350 million years ago, animals leaving the water had to avoid drying out. They changed their metabolism to save body water 🐸 #aestivation
We still carry that ancient program. We study how this link between water conservation and energy metabolism may shape aging and disease 💧 #SciSky