Could altered fat metabolism be driving #vasculitis?
This study links enhanced fatty acid–acetyl-CoA flux and #ACSL4 activity in monocytes from pediatric #AAV patients to TGF-β and CD48 signaling, revealing new therapeutic targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Resident immune cell neighborhoods associate with protein kinase pRIPK3 and fatty acid ligase FACL4 expression during cell injury in ANCA associated vasculitis and #lupusnephritis

doi.org/10.1016/j.kint.2026.07.031

#NephSky #MedSky #OpenAccess #glomerulardisease @yaleschoolofmed.bsky.social #AAV

The story is not only about vector design. It includes patient-derived organoids, animal studies, biodistribution, toxicology, GMP manufacturing, dose selection, and years of regulatory preparation before the first patients can be treated.

#GeneTherapy #AAV #RareDiseases

📆First day of the #CGMESA26 ! We look forward to seeing everyone this week.
Don’t miss @genethonfr.bsky.social activities presentation by Imen Mestiri, PhD, Business Development and Licensing Lead October 5th at 9:30 am to 9:45 am, FLW Ballroom F.

#Congress #GeneTherapy #ClinicalTrial #AAV

Klug, et al. utilized EnvA-SAD-B19-RVΔG tdTomato & AAV8-DIO-BACE-HA in our catalog to perform transsynaptic tracing of the CA1 by combining retrograde and anterograde tracing. doi.org/10.1007/s004... #hippocampus #brainmapping #rabiesresearch #AAV #Neuroscience #UCI #Neuro