Can microbial exposure strengthen pulmonary host defense?

#Pseudomonas aeruginosa LPS primes lung-resident NK cells through C3aR1, enhancing IFN-γ production and LFA-1-dependent adhesion to protect against #BacterialPneumonia.

#STTT #OpenAccess: doi.org/10.1038/s413...

How do signaling networks guide #CellDifferentiation in health and disease?
This review explores Wnt, Notch, Hedgehog, TGF-β, and Hippo pathways, their regulatory crosstalk, disease roles, and potential for targeted therapies.
#STTT #OpenAccess: doi.org/10.1038/s413...

Can precision retinoid therapy overcome therapeutic resistance?

This review defines “retinoid endotypes” shaped by metabolic niches, chromatin state, and #microenvironmental cues to inform patient stratification and precision therapy.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Immunology

Chromosomal instability can drive tumor evolution while creating exploitable dependencies. This review connects the sources and consequences of CIN with tolerance pathways, emerging diagnostics, and therapeutic vulnerabilities.

#STTT #OpenAccess: doi.org/10.1038/s413...

#MolecularOncology

Researchers discover that rapid transcriptional elongation and pause release induced by SEC-driven RNA pol II promote endothelial plasticity & plaque vulnerability, offering a #TherapeuticTarget for #Atherosclerosis.

#STTT #OpenAccess: doi.org/10.1038/s413...

Could targeted nanomedicine protect the brain by restoring mitochondrial function?
In a #ParkinsonsDisease model, peptide-targeted #Nanoassemblies enable nose-to-brain delivery, promote mitochondrial biogenesis and #Neuroprotection, and reduce #Neuroinflammation.

#STTT doi.org/10.1038/s413...

Bacteria-derived PAMPs can reprogram macrophage responses against #Cancer cells.

This study shows that PAMP-decorated cancer cells activate pattern recognition receptor pathways, enhancing macrophage #Phagocytosis and antitumor activity.

#STTT #OpenAccess: doi.org/10.1038/s413...

How can #Cancer #Vaccines generate stronger immunity?

Protein condensate nanoadjuvants enhance antigen cross-presentation and activate DCs via mtDNA leakage-driven cGAS–STING signalling, promoting CD8⁺ T-cell antitumour responses.

#STTT #OpenAccess: doi.org/10.1038/s413...
#TumorImmunology

Who benefits most from consolidation #Immunotherapy in limited-stage #SCLC?
Integrating #ctDNA status with tumor shrinkage identifies high-risk patients deriving survival benefit, while sustained ctDNA negativity predicts favorable outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...