Abatacept suppresses T cell activation, but how durable is its effect?
Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬
@discovimmunol.bsky.social
@discovimmunol.bsky.socialAbatacept suppresses T cell activation, but how durable is its effect?
Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬
@bionewscentral.comA new approach can program #NaturalKillerCells inside the body, showing promise for treating diseases linked to dysfunctional #TCells, including #lymphoma and #AutoimmuneHepatitis.
#AutoimmuneDisease #Immunotherapy
@francejeunes.bsky.socialVaccin universel respiratoire : ce que l'étude de Stanford démontre, et ce qu'elle ne démontre pas ❓ Qu'est-ce que le vaccin universel respiratoire de Stanford ? ❓ Que démontre l'étude chez la souris ? ❓ Que ne démontre pas l'étude ? #tcells #covid19 #influenza
@discovimmunol.bsky.socialPathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬
@imtadvances.bsky.socialA high-affinity ImmTAC® bispecific efficiently redirects T cells to target PRAME+ tumour cells, even at very low antigen levels, highlighting its promise across multiple cancers 🧬
@discovimmunol.bsky.socialRNA capping emerges as a key checkpoint in T cell activation: RAM upregulation is essential for RNA cap formation, gene expression, and proliferation, linking transcriptional control to immune function. 🧬
@imtadvances.bsky.socialA simple whole-blood assay enables rapid, in vivo monitoring of engineered TCR T cell function, capturing cytokine responses post-transfer without complex processing. A practical step for tracking cell therapy performance. 🧬
@wealthwise-dca.bsky.socialVoyager Technologies signed a contract with the Center for the Advancement of Science in Space to manage Symphony Biosciences’ cancer research experiment aboard the ISS.
#VOYG #VoyagerTechnologies #Space #SpaceTech #ISS #CancerResearch #Biotech #SpaceBiotech #Microgravity #Oncology #TCells
@discovimmunol.bsky.socialSingle-cell insights reveal how “periodic” TCR signalling shapes self-reactive T cells, and how HTLV-1 exploits this pathway. A fresh model with implications for cancer and immunotherapy. 🧬
Read here: vist.ly/5mcnr
@plosbiology.org#TrendingNow | Within the #TumorMicroenvironment, cells engage in dynamic metabolic competition. This Essay discusses metabolic crosstalk between #cancer cells and #TCells, highlighting metabolic targeting as a promising strategy to reprogram anti-tumor immune responses 🧪 #ICYMI plos.io/3U6RWir
@thecancersurvivorsclub.comCancer-fighting T cells can become exhausted before the job is done. Scientists have identified a way to help them conserve energy and keep fighting for longer, potentially improving several forms of immunotherapy.
@dctomaz.bsky.social🧬 PD-1 can suppress LAT condensate formation through unphosphorylated tyrosines. Reconstitution and T-cell experiments support a phosphorylation-independent route to inhibition and possibly new immunotherapy avenues.
doi.org/10.1126/scie...
#Immunology #TCells
@jem.orgSlow-cooked naïve #Tcells make better effectors. Hee Yeun Won and Jung-Hyun Park (National Cancer Institute) discuss new study from Yamato Sajiki, Koichi Araki et al. @arakilab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
@discovimmunol.bsky.social🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development.
@aegeanconf.bsky.social👏 A special thank you to the organizers of the 1st International Conference on T Cells in Health and Disease for a wonderful meeting! 🧬🇬🇷
Congratulations on a fantastic conference. We look forward to seeing everyone again in 2 years!
@aegeanconf.bsky.social🎓 Congratulations to our 19 Trainee Travel Award recipients at the 1st International Conference on T Cells in Health and Disease! 🧬
Proud to support the next generation of scientists! 👏
@elviraforte.bsky.social2/2 Applied in the context of ankylosing spondylitis, StriMap successfully shortlisted candidate molecular mimics out of 13 million bacterial peptides, which were experimentally validated.
website available at: www.strimap.com
#Tcells #AIinBio #Immunology #ComputationalBiology #ScienceNews
@rupress.orgInsights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...
@jem.orgInsights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...
@talius2.bsky.social#Experimental #cancer #vaccine makes its #own #oxygen and gives #Tcells a #boost
NW researchers developed a cryogel vaccine that generates local oxygen to prevent tumor hypoxia from shutting down T cells, dramatically extending survival in mice >> scitechupdates.com/e...
