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@labmonteiro.bsky.socialOct 15, 2026, 8:26 PM

PhD project available through @MIBTP (BBSRC-funded)
investigating how blood flow instructs the embryo to make blood stem cells.
A wet lab+computational project for anyone interested in stem cells, development and systems biology.

Please share!
#PhD #StemCells #Zebrafish #SystemsBiology #BBSRC

@signalfield.bsky.socialOct 14, 2026, 8:05 PM

Life was electrical before thought.

Cells hold voltage across membranes.
Tissues coordinate.
Networks emerge.

The beautiful systems question is what becomes possible when many local signals begin acting together.

#SignalScienceLab #Bioelectricity #SystemsBiology

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Y@yaowu1960.bsky.socialOct 13, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

@evgenii-protasov.bsky.socialOct 13, 2026, 6:17 AM

Higher-order assembly and emergent persistence in biology
#biology #SystemsBiology #MicroSky
www.sciencedirect.com/science/arti...

Y@yaowu1960.bsky.socialOct 12, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

@csbj.orgOct 12, 2026, 4:54 AM

šŸ”— A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition. doi.org/10.34133/csb...

šŸ“š CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

@embl.org @csbj.org #SystemsBiology #Thrombosis

A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0228 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
Y@yaowu1960.bsky.socialOct 11, 2026, 12:00 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

Y@yaowu1960.bsky.socialOct 10, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

Y@yaowu1960.bsky.socialOct 9, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

Y@yaowu1960.bsky.socialOct 8, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

Y@yaowu1960.bsky.socialOct 6, 2026, 12:01 PM

Biologists: what makes many parts one living system?
This theoretical framework examines boundaries and relations. Which assumption would you test?
Yao Wu ā€” Independent Researcher
doi.org/10.5281/zeno...
#Biology #SystemsBiology

@royalsocietypublishing.orgOct 5, 2026, 11:01 AM

New #JRSocInterface research uses computer modelling to reveal how rhythmic pumping and valves in cervical lymphatic vessels work together to drain waste from the brain, offering insights that could help inform future treatments doi.org/10.1098/rsif... | #Bioengineering #Biomechanics #SystemsBiology

@csbj.orgSep 28, 2026, 8:40 PM

šŸ”— Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations. doi.org/10.34133/csb...

šŸ“š CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

@csbj.org #scRNAseq #SingleCellOmics #Transcriptomics #SystemsBiology #CellBiology #Omics

Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0087 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
@fds3rd.bsky.socialSep 26, 2026, 6:01 PM

Bacteria against Mutants
#StemCells #SystemsBiology #Viruses #Microorganisms #Evolution #Development

@fds.wsocial.euSep 26, 2026, 6:01 PM

Bacteria against Mutants
#StemCells #SystemsBiology #Viruses #Microorganisms #Evolution #Development

@royalsocietypublishing.orgSep 19, 2026, 9:00 AM

New research from #JRSocInterface: Cycling cadence selections at different saddle heights minimize muscle activation rather than energy cost doi.org/10.1098/rsif... | #Biomechanics #Biophysics #SystemsBiology

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@alicefrolov.bsky.socialSep 18, 2026, 5:01 PM

Cell-fate partitioning after senescence induction: modeling SASP-driven escape trajectories

#CellularSenescence #SASP #CellCycleReentry #SenescenceEscape #TumorSuppression #NFkBSignaling #SystemsBiology #ComputationalCellBiology

Cell-fate partitioning after senescence induction: modeling SASP-driven escape trajectories I am sharing a data visualization that formalizes an increasingly discussed but underappreciated phenomenon in the senescence literature: the capacity of a subpopulation of arrested cells to re-enter the cell cycle rather than remaining stably arrested or undergoing clearance. The figure, titled "Cell-fate partitioning after senescence induction," uses a bidirectional flow trajectory (streamgraph-style stacked area) to render the temporal redistribution of an initial senescent-induced cohort across three terminal or quasi-terminal states over a 30-day window: stable arrest, apoptotic clearance, and senescence escape. The subtitle emphasizes that these are simulated dynamics, not empirical measurements; the parameterization is literature-grounded, calibrated to reported ranges for p16INK4a/p21CIP1 durability, SASP factor accumulation kinetics, and escape frequencies observed in oncogene- and therapy-induced senescence models. The streamgraph format is deliberate. Because escape is a flux phenomenon rather than a static endpoint, the bidirectional banding captures net transitions between compartments, including the small but non-negligible reflux from a metastable arrested state back into proliferation. The simulation encodes a positive-feedback term whereby paracrine and autocrine SASP components ā€” principally IL-6, IL-8, and other NF-ĪŗB-dependent secreted factors ā€” lower the effective barrier to CDK reactivation in cells with attenuated tumor-suppressor signaling. The escape band consequently widens after the SASP matures, roughly days 8 to 15 in this parameterization, consistent with the delayed secretory phenotype. I would welcome critique on the transition-rate assumptions, particularly the coupling coefficient between SASP intensity and escape probability, which remains poorly constrained empirically.
@pablonavarrolab.bsky.socialSep 17, 2026, 12:26 PM

šŸ§¬ How do cells remember?

Join us in beautiful Baeza šŸ‡ŖšŸ‡ø for Transcriptional Memory in Health and Disease, 20ā€“22 October.

šŸ’„ Young scientists: ā‚¬250, including meals!

šŸ“¢ Deadline extended to 27 September ā€” you can do this!

www.unia.es/estudios-y-a...

#Epigenetics #Chromatin #SystemsBiology

@fds.wsocial.euSep 15, 2026, 6:53 PM

A Broken Heart: Two Types of Scars, Two Paths to Healing
#Bioinformatics #ComputationalBiology #SystemsBiology #MolecularBiology #CellBiology #Disease #Drugs #Diagnostics

@fds3rd.bsky.socialSep 15, 2026, 6:53 PM

A Broken Heart: Two Types of Scars, Two Paths to Healing
#Bioinformatics #ComputationalBiology #SystemsBiology #MolecularBiology #CellBiology #Disease #Drugs #Diagnostics

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