@sigtrans-sttt.bsky.socialCan host lipid metabolism help combat drug-resistant #Biofilms?
This study shows that rhein activates LDLR-mediated fatty acid production, enabling synergy with silver ions to suppress biofilms and promote #DiabeticWoundHealing.
@sigtrans-sttt.bsky.socialAdvanced #SCLC requires innovative therapeutic strategies beyond standard #Chemoradiotherapy.
A randomized trial reports improved progression-free and overall survival with camrelizumab-based induction and consolidation therapy.
@sigtrans-sttt.bsky.socialCan dual cytokine blockade address treatment-resistant #HidradenitisSuppurativa?
This study identifies an IL-17/IL-36γ inflammatory hub and demonstrates promising clinical responses and tunnel regression with the #BispecificAntibody HB0043.
@sigtrans-sttt.bsky.socialLearn how protein stabilization protects against #PulmonaryFibrosis.
Nedd4L promotes K63-linked BMPR2 #Ubiquitination, counteracts #LipidPeroxidation-induced degradation, and preserves antifibrotic BMP/Smad signaling.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialHow does tumor metabolism contribute to immune escape?
This review defines metabolic immune checkpoints involving protein modifications, metabolic enzymes, and microbial metabolites as potential #Immunotherapy targets.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Immunometabolism #ImmuneEscape
@sigtrans-sttt.bsky.socialHow can #Bioengineering improve #mRNAvaccine #Immunogenicity?
This review explores how RNA architecture and delivery platforms coordinate antigen expression, innate immune activation, and adaptive immune responses.
@sigtrans-sttt.bsky.socialPulmonary hypoxia and #Inflammation may influence dormant tumor growth.
#SARSCoV2 infection activates #VEGF–VEGFR2 signaling, driving angiogenesis and tumor outgrowth in animal models, which VEGF blockade suppresses.
@sigtrans-sttt.bsky.socialThis study shows that #eccDNA-derived circular MIR144 drives age-related #CardiacRemodeling by inducing cardiomyocyte senescence and by promoting interstitial fibrosis and systolic dysfunction in mice.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialThis review explores how local, reflex-level, and central #Neuroimmune interactions influence #Tumors, immune-related disorders, and #Infections, identifying therapeutic opportunities and challenges in clinical translation.
@sigtrans-sttt.bsky.socialResearchers reveal how glycerol-derived lactate drives H4K5 histone #Lactylation and a FOXP3–GK feedback loop in regulatory T cells, enhancing #Immunosuppression in #ColorectalCancer liver metastases.
@sigtrans-sttt.bsky.social#WorldArthritisDay | October 12
#Arthritis research is uncovering inflammatory pathways and molecular targets that could advance diagnosis and targeted treatment.
#STTT explores signal transduction and targeted therapies across human diseases.
Read recent research: www.nature.com/sigtrans/
@sigtrans-sttt.bsky.socialUsing comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress.
@sigtrans-sttt.bsky.socialHow does α7 integrin drive HPV-negative head and neck cancer (#HNSCC)?
Researchers reveal that ITGA7 regulates chromatin accessibility and gene expression through an AURKA-centered axis, identifying a potential #TherapeuticTarget. @tudresden.bsky.social
@writteninmusic.mastodon.nl.ap.brid.gyRecensie: Content Blocks – Hard Out
https://writteninmusic.com/albumrecensie/content-blocks-hard-out/
@sigtrans-sttt.bsky.socialResearchers reveal how #Connexin43-mediated mitochondrial transfer from mesenchymal stem cells activates PGC1α signaling, reducing #OxidativeStress and #Inflammation to improve renal recovery after #Ischemia-reperfusion injury.
@sigtrans-sttt.bsky.socialPost-translational modifications can coordinate metabolic and immune adaptation in #Cancer. This review links PTM networks to metabolic flux, cell fate, #ImmuneEvasion, and emerging targets for metabolic therapy and #Immunotherapy.
@sigtrans-sttt.bsky.socialHow does immune cell trafficking shape tumors and #Inflammation?
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
@sigtrans-sttt.bsky.socialHow do intrinsic and acquired mechanisms drive cancer drug resistance?
This review details the mechanisms underlying resistance, highlighting emerging therapeutic strategies for overcoming resistance in #PrecisionOncology.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerResearch #Oncology
