@genesndiseases.bsky.socialHow does the gut sense mechanical forces?
This review explores #Piezo1 and #Piezo2 in intestinal motility, barrier integrity and host–microbiota balance, while linking their dysregulation to #GIdiseases and cancers.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@pantazislab.bsky.social🚀 Excited to share our latest preprint demonstrating how GenEPi enables real-time visualisation of Piezo1 activity, revealing how mechanical forces and cellular history shape mechanosensitive signalling!
@sigtrans-sttt.bsky.social#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis
@isev.org🆕New in #JEV🆕 Shear Stress-Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance #extracellularvesicles #exercise #piezo1 #shearstress isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
@ijosjournal.bsky.socialIn mice, removing both #Piezo1 and #Piezo2 slowed the maturation of dentin-forming odontoblasts and reduced Wnt/β-catenin signaling. Adding #Wnt10a restored odontoblast development in cultured tooth germs, connecting mechanical sensing with #tooth development.👇
www.nature.com/articles/s41...
@granuccilab.bsky.socialWhat if PRRs are not the first to sense #infection?
🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com
Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment.
🔗 www.nature.com/articles/s41...
@isev.org🆕New in #JExBio🆕 Engineering Piezo1-Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading #extracellularvesicles #bioluminescence #piezo1 #proteomics isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
