Great pleasure to attend the @embo.org meeting on Organelles dynamics in Health and Disease in Edinburgh, chairing a session and presenting 3 posters of the lab on #phagocytosis #hiv mannose receptors phagosome maturation in #macrophages @institutcochin.bsky.social @cnrsbiologie.bsky.social

#OxidativeStress -induced #microglial CD22 upregulation impairs #phagocytosis and exacerbates #Huntingtons disease

Yan Hua Lee, Jian Jing Siew, Chia-Wei Lee...Takashi Angata & Yijuang Chern

link.springer.com/article/10.1...

Carlos Blanco-Camarillo and colleagues report that #Obesity induces elevated numbers of low-density #Neutrophils (LDN), but these perform #Phagocytosis and #NETosis less efficiently than LDN from individuals with normal weight

#Phagocytosis inhibition as therapy.
Berberine suppressed NF κB signaling, reduced cytokines, and attenuated LPS induced #Inflammation by targeting PI3K CDC42 WASP Arp2/3. #medsky #Immunology
#AMM #OpenAccess: doi.org/10.15212/AMM...

Mitoferrin-1 sustains a NET histone–TLR9–IFNAR1 circuit that rewires neutrophil metabolism and promotes inflammatory tissue damage, revealing a strategy to restrain pathogenic responses while preserving #Phagocytosis.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Inflammation #ChronicInflammation

Bacteria-derived PAMPs can reprogram macrophage responses against #Cancer cells.

This study shows that PAMP-decorated cancer cells activate pattern recognition receptor pathways, enhancing macrophage #Phagocytosis and antitumor activity.

#STTT #OpenAccess: doi.org/10.1038/s413...