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@tomkindlon.bsky.socialOct 14, 2026, 12:36 AM

NIH's clinical trials program for Long COVID, RECOVER-TLC (Researching COVID to Enhance Recovery-Treating Long COVID) will host a 2-day workshop

web.cvent.com/event/e0be40...

Screenshot from MassME October newsletter

#LongCovid #PASC #PwLC #postcovid

RECOVER-TLC Two Day Workshop NIH's clinical trials program for Long COVID, RECOVER-TLC (Researching COVID to Enhance Recovery-Treating Long COVID) will host a two-day workshop on Wednesday, November 4 and Thursday, November 5 to provide updates and discuss opportunities via plenary speakers, panel discussions, and networking. Attend in person in Bethesda, Maryland or join by Zoom. Register here.
@tomkindlon.bsky.socialOct 13, 2026, 12:23 AM

From the UK

Choroid plexus enlargement in Post-COVID-19 syndrome is linked to Serum-Induced cytokine secretion in human hippocampal progenitors

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Choroid plexus enlargement in Post-COVID-19 syndrome is linked to Serum-Induced cytokine secretion in human hippocampal progenitors — Martins et al "By demonstrating that CP enlargement tracks functional immune effects in human neural cells rather than peripheral cytokine concentrations, our findings highlight the importance of moving beyond circulating biomarkers to understand immune–brain coupling in post-infectious syndromes." Article | Thread
@tomkindlon.bsky.socialOct 12, 2026, 9:00 PM

2/
“Among the changes associated with long-Covid symptoms, was an over-abundance of bacteria that produce lactic acid, and this was also linked to signs of inflammation found in samples of patients' blood.”

#LongCovid #PASC #PwLC #postcovid

@tomkindlon.bsky.socialOct 12, 2026, 6:37 PM

UK research

News Release 11-Oct-2026

People with long Covid have drastically different microbiome in their lungs and mouth
www.eurekalert.org/news-release...

Paper:
publications.ersnet.org/content/erj/...

Hospitalised cohort so unclear if similar in different types of patients

#LongCovid #PASC

News Release 11-Oct-2026 People with long Covid have drastically different microbiome in their lungs and mouth Peer-Reviewed Publication European Respiratory Society FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail A study of more than 700 people has shown that those with long Covid have distinct differences in the mix of bacteria that live in their mouths and lungs, according to a study published today (Monday) in the European Respiratory Journal [1]. The research also shows that these differences in the lung microbiome are linked to respiratory symptoms, as well as the cognitive and digestive problems known to occur in long Covid. Researchers say their findings may shed light on why some people develop long Covid and they could point to new ways to treat the condition. The lead author of the study was Dr Daniela Alferes de Lima Headley from the University of Dundee, UK. She said: “We know that millions of people worldwide are still affected by long Covid and its cause is still unknown. Long Covid affects multiple organs. The microbiome is important to maintain health throughout the body, so it is a strong candidate for something that may contribute to long Covid. Prior studies have shown some changes in the gut microbiome with long Covid, but Covid is a lung disease and so it makes sense to look to see if the lung microbiome is changed in long Covid.”
@tomkindlon.bsky.socialOct 11, 2026, 8:57 PM

NIH: New pathobiology studies look to accelerate RECOVER’s progress

recovercovid.org/news/new-pat...

"Researchers aim to build on past findings in ways that can help inform future clinical decision-making for people at high risk of or already experiencing Long COVID."

#LongCovid #PASC #PostCovid

@tomkindlon.bsky.socialOct 9, 2026, 12:02 AM

From Ireland

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC)

onlinelibrary.wiley.com/doi/10.1155/...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC) — Marmont et al "six distinct inflammatory clusters were identified within people with PASC, three of which showed elevated biomarkers related to tissue damage and repair, coagulation, axonal injury, and antiviral immune responses and were associated with component 3 of the complement pathway." Article | Thread
@tomkindlon.bsky.socialOct 8, 2026, 11:51 PM

From the US

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing

www.mdpi.com/2673-4087/7/...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing — White et al "Taken together, these findings clearly indicate that even mild PASC is associated with significant alterations in cell signaling, characterized by oscillatory slowing." Article | Thread
@tomkindlon.bsky.socialOct 8, 2026, 12:46 AM

From Germany

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #PASC

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection — Faraj et al "Our data further support the conjecture of a dysregulated immune system after COVID-19, and endorse former observations that there is no direct link between autoantibody prevalence and clinical symptoms of Post-COVID syndrome." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 1:29 AM

From Austria

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans

portlandpress.com/clinsci/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans
@tomkindlon.bsky.socialOct 6, 2026, 1:22 AM

From Austria

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #depression #Dysautonomia #NeuroPASC #PASC

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth — Oehlke et al "Without a healthy reference, it cannot be determined whether HCC or HRV indices in either clinical group deviate from normative physiological levels, nor whether the observed patterns are specific to LC or depressive disorders. Accordingly, the present findings should be understood as relative differences between the two clinical groups." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 1:15 AM

From Ireland

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome

Screenshot from latest Science for ME weekly update

#LongCovid #POTS #Dysautonomia #NeuroPASC #PASC

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome — O’Brien et al "Patients from this cohort with LCS, dysfunctional breathing and hypocapnia based on the lean test were referred for targeted pulmonary rehab." "There was no significant change in end-tidal CO2 or heart rate following the intervention." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 12:33 AM

From the US

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature

insight.jci.org/articles/vie...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #PASC

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature — Chakravarty et al "Across tissue-based assays and peptide-level, whole-human-proteome PhIP-Seq profiling, the data consistently reveal a lack of convergent, disease-specific autoantibody signatures." Article | Thread
@tomkindlon.bsky.socialOct 2, 2026, 12:41 AM

From Sweden

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity

www.thelancet.com/journals/ecl...

Screenshot from Science for ME update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al "we demonstrate that receiving a fourth dose of COVID-19 vaccine is associated with a decreased risk of being diagnosed with post COVID-19 condition during the first 6 months after vaccination, although the incidence rate difference was small." Article | Thread
@tomkindlon.bsky.socialOct 1, 2026, 12:34 AM

From the UK

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial

dx.doi.org/10.1093/oxfi...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al "The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" "whilst improvements were observed in health-related quality of life, the mean change in EQ-5D-5L index score (0.06) did not exceed the published MCID of 0.11" "Improvements could reflect natural fluctuation in symptom burden, behavioural modification associated with trial participation, or expectation effects." Article | Thread
@tomkindlon.bsky.socialSep 30, 2026, 12:30 AM

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #postcovid #postcovid19

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al "our focused examination of both global and regional volumetric changes not only provides deeper spatial insights compared to previous primary studies but also addresses the substantial methodological heterogeneity" "Results highlighted that while either global or local alteration was reported by independent studies, this evidence remains unsupported when they are considered on a meta-analytic level."
@heytheremaggs.bsky.socialSep 29, 2026, 5:15 PM

Hi #LongCovid / #MECFS friends. What is the going feeling on the actively recruiting phase 3 Baricitinib trial?

#NEISvoid #ClinicalTrial #Study #Science #Covid #RCT #REVERSE-LC #PostCovid #Covid19 #PASC #MoHashtagsMoProblems

@monalisarout1701.bsky.socialSep 28, 2026, 6:08 AM

Paxlovid in Acute COVID-19: PASC Prevention Insights
🔹 445,738 patients examined
🔸 Negligible effect on overall PASC

#PASC #COVID19 #Paxlovid https://tnyp.me/f8Q353pu/s

Photo, no description
@monalisarout1701.bsky.socialSep 28, 2026, 6:04 AM

Paxlovid in Acute COVID-19: PASC Prevention Insights
🔹 445,738 patients examined
🔸 Negligible effect on overall PASC

#PASC #COVID19 #Paxlovid https://tnyp.me/f8Q353pu/s

@tomkindlon.bsky.socialSep 25, 2026, 5:16 PM

NEWS RELEASE 23-SEP-2026

UTHealth Houston database fills gap in Long COVID surveillance

www.eurekalert.org/news-release...

#LongCovid #PASC

@tomkindlon.bsky.socialSep 25, 2026, 5:15 PM

NEWS RELEASE 23-SEP-2026

UTHealth Houston database fills gap in Long COVID surveillance

www.eurekalert.org/news-release...

#LongCovid #PASC