#TCellExhaustion can protect grafts but weaken immunity.
This review explores metabolic and #epigenetic regulation of exhaustion, highlighting strategies to promote graft tolerance while limiting risks. #MetabolicReprogramming
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

How does macrophage zinc accumulation worsen #MASLD progression?

Macrophage zinc trapping activates IRE1α–XBP1s signaling, promoting IL-1β-driven #MetabolicReprogramming and lipid transfer to hepatocytes, driving liver inflammation.

#STTT #OpenAccess: doi.org/10.1038/s413...

#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery

Myeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.

#STTT #OpenAccess: doi.org/10.1038/s413...