@iocbprague.bsky.social#research #IOCB #IOCBPrague #czechscience #chemistry #medchem #drugdiscovery
Kocek, H.; Vaško, M. et al., Boura, E.; Nencka, R. First-in-Class Inhibitors of the Protein Lysine Methyltransferase METTL21A. @EuroMedChem 2026, 119227. doi.org/10.1016/j.ejmech.2026.119227
@pwk2024.bsky.socialFieseler et al Syndirella: synthesis-directed fragment elaboration enables extensive and cost-effective binding site exploration beyond catalog compounds. Chem Sci 2026 #FBD #FBDD #MedChem #SynChem #cheminformatics #OpenAccess #chemsky 🧪🔓
doi.org/10.1039/d6sc...
@stephanhacker2.bsky.socialGianluca Sbardella opened the third day of #ICBS2026 and introduced the EFMC - European Federation for Medicinal Chemistry and Chemical Biology and the EFMC Young Scientists Network.
@rscmedchem.rsc.org🔓Take a look in our latest issue at #OpenAccess research by David M. Andrews, Fraser Hof et al. reporting the synthesis and structure–activity relationships of small-molecule 2-pyridone based CBX7 inhibitors #medchem 🧪
@pwk2024.bsky.socialAn excellent read and also relevant to ML modelling of bioactivity: Srinivasan & Lloyd, Ki Revisited: Principles, Pitfalls, and Best Practices for Measuring Enzyme Inhibitor Affinity. JMC 2026 #biochem #MedChem #cheminformatics #FreeToRead #chemsky 🧪
doi.org/10.1021/acs....
@medchemres.bsky.socialMedicinal Chemistry Research announces a special collection honoring Mark S. Cushman on his induction into the ACS MEDI Hall of Fame.
Commentaries, reviews, brief reports & research articles welcome — due April 30, 2027.
@pwk2024.bsky.socialOpportunity for an Application Scientist to provide maternity cover at Optibrium (Cambridge UK) duration: 12 months #MedChem #CADD #cheminformatics #CompChem #UKChemJobs #ChemJobs #chemsky 🧪
optibrium.com/jobs/applica...
@launchscience.bsky.socialSmall detail in chemkit-lite: invalid SMILES in your hit list are reported, not silently dropped. Salts are stripped and structures neutralized before MW, cLogP or TPSA are computed. Free and MIT licensed.
github.com/chdominguez/chemkit-lite
#RDKit #medchem
@rscmedchem.rsc.org🔓Be sure to read this #OpenAccess paper from J. Mark Sutton, Khondaker Miraz Rahman & co. @kingscollegelondon.bsky.social in our latest issue designing and evaluating azole antifungals against multidrug-resistant Candida auris #medchem 🧪
Find their full report here👇
doi.org/10.1039/d6md...
@pwk2024.bsky.socialA most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...
@rscmedchem.rsc.orgDon't miss this review in our latest issue from Lei Wang, Qiuyue Zhang et al. at China Pharmaceutical University discussing how protein phosphorylation can be modulated by proximity-inducing strategies #medchem
Check it out in full below🔽
doi.org/10.1039/d6md...
@pwk2024.bsky.socialGehringer & Heppner, In Pursuit of Enduring Inactivation: A Perspective on the Development and Study of Irreversible-Covalent Inhibitors. Biochemistry 2026 #biochem #biophys #MedChem #ChemBiol #OpenAccess #chemsky 🧪
doi.org/10.1021/acs....
@rscmedchem.rsc.org🔓Check out #OpenAccess research by Bernhard Wünsch & co. @uni-muenster.de in our latest issue synthesising γ-amino alcohols embedded in a 1-benzoxepine scaffold as novel ligands of NMDA receptors with GluN2B subunit #medchem
Read in full on our website👇
doi.org/10.1039/d6md...
@pwk2024.bsky.socialOpportunity for medicinal chemist at Isomorphic Labs (Cambridge MA USA) #MedChem #SynChem #ChemJobs #chemsky 🧪
job-boards.greenhouse.io/isomorphicla...
@medchem1.bsky.socialWhat if a protein that's meant to protect your brain can sometimes go rogue? 🧠
Read more about the Weaver Lab's emerging hypothesis of beta amyloid contributing to #Alzheimers disease, as featured in #UofT magazine:
@rscmedchem.rsc.org⌛There's less than a month left until nominations close for the 2027 @rscmedchem.rsc.org Emerging Investigator Lectureship!
If you know an up-and-coming researcher in drug discovery don't miss the opportunity to nominate them #chemsky #medchem
Full details on how to nominate▶️ rsc.li/md-lectureship
@fabermdphd.bsky.social@pwk2024.bsky.socialA most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...
@orgbiomolchem.rsc.org🔓Be sure to read this #OpenAccess paper by Zihuan Fu & Heather D. Maynard @uclacb.bsky.social in our latest issue describing how alternating iterative exponential growth oligomers serve as a platform for hydrophilic antibody–drug conjugates #medchem #orgchem
Find it in full👇
doi.org/10.1039/d6ob...
@americanpeptidesociety.org