How does dysregulated RTK signaling contribute to disease?

This review examines RTK interactions with #GPCR, Wnt, and TGF-β pathways and their implications for #Cancer progression and targeted therapeutic development.

#STTT #OpenAccess: doi.org/10.1038/s413...

First first-author paper from my PhD journey ✅

Thanks to our funders: DFG, IRTG2466, CEPLAS & CRC1535

Could similar host-dependent signaling mechanisms be hiding in other fungi? Stay tuned for more!

Read the paper: rdcu.be/1B1vdJsRPpua

#GPCR #FungalBiology #PlantPathology

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#GPCR antagonism via rewiring of #receptor trafficking and degradation
doi.org/10.1038/s415...

GPCRvp, a GPCR-specific variant impact predictor, decodes GLP1R missense variants using molecular dynamics + AI. It sharply reduces false positives vs AlphaMissense and improves prediction of GLP 1 drug response. #GLP1R #GPCR #Diabetes #Obesity link.springer.com/article/10.1... 🔓

Cover feature in Science Signaling: The Kathleen Caron Lab identified MYO6 as a regulator of signaling in lymphatic cells, revealing a previously unknown mechanism controlling lymphatic endothelial cell signaling and behavior.

doi.org/10.1126/scis...

@science.org

#Lymphatics #GPCR #UNCResearch

Structure beats sequence: AlphaFold2 reveals "superdark" GPCR-like proteins hiding in the dark proteome. TM184C links GPCR signaling #Proteomics #AlphaFold #GPCR #DarkProteome

https://freegardner.com/sci_scout/structure-reveals-hidden-gpcr-like-proteins-in-dark-proteome.html