#Autophagy may help overcome #CisplatinResistance in #GastricCancer.
This review explores autophagy’s role in tumor survival and death, highlighting drugs and emerging targets that could restore cisplatin sensitivity.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#Obesity may accelerate biological #aging.
This review links obesity with systemic inflammation, telomere loss and mitochondrial dysfunction, highlighting #AntiObesity therapies as potential anti-aging strategies.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#EpigeneticDysregulation can drive #cancer.
This review highlights CXorf67’s roles in PRC2 regulation, histone modification and #DNArepair, linking it to multiple malignancies and highlighting its potential as a therapeutic target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could m6A RNA modification link toxicant exposure to #neurodegeneration?
This review explores how #m6A regulates neural development and gene expression and its emerging role in #toxicant-related nervous system disorders.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could #ferroptosis overcome treatment resistance in #ProstateCancer?
This review highlights key regulatory pathways, biomarkers and combination strategies with anti-androgen therapy, chemotherapy and #immunotherapy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#TCellExhaustion can protect grafts but weaken immunity.
This review explores metabolic and #epigenetic regulation of exhaustion, highlighting strategies to promote graft tolerance while limiting risks. #MetabolicReprogramming
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

#FabryDisease can cause irreversible organ damage.
This review highlights how #omics approaches reveal disease mechanisms, #biomarkers and therapeutic targets, supporting earlier diagnosis and precision treatment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

How does the gut sense mechanical forces?
This review explores #Piezo1 and #Piezo2 in intestinal motility, barrier integrity and host–microbiota balance, while linking their dysregulation to #GIdiseases and cancers.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Not all cancers fit traditional classifications.
This review highlights #POU2F3-driven #TuftCell-like tumours as a distinct cancer subtype with unique biology, immune features, and potential value for prognosis and targeted therapy.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#Diabetes may leave a lasting imprint on immunity.
This review explores how #TrainedImmunity links metabolic dysregulation to diabetes and its complications, highlighting therapeutic opportunities to target innate immune memory.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Understanding #HBV-driven #LiverCancer could improve early detection.
This review highlights dysregulated #lncRNAs as regulators of viral replication and cancer, with potential as biomarkers and therapeutic targets.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could reactivating a silenced X chromosome transform #XLinkedDisorder treatment?
This review explores skewed #XChromosomeInactivation, its impact on disease severity, and emerging Xist-targeted strategies to restore silenced alleles.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#FOXP3 may do far more than regulate T-cell immunity.
This review explores its emerging roles in #cancer cells, fibroblasts, #cardiomyocytes and endothelial cells, including metabolism, regeneration and signaling crosstalk.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Variant interpretation remains challenging in rare diseases.
This review highlights the potential of #AI to enable variant classification, #radiomics, and therapy optimization for #LysosomalStorageDisorders while addressing data and ethical barriers.
#GenesAndDiseases: doi.org/10.1016/j.ge...

#IUGR can severely impair muscle development.
This study identifies #METTL1-mediated m7G methylation as a key regulator, showing that eIF3a mRNA stabilization supports protein synthesis and #MuscleGrowth.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Could #GeneTherapy move #Phenylketonuria treatment beyond #DietaryRestriction?

This review explores #CRISPRCas9, base and prime editing, gene replacement and mRNA therapies to restore PAH activity, while addressing challenges.

#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

One RNA-modifying enzyme can influence #cancer across multiple tumors.
This review explores FTO’s context-dependent roles in cancer through #m6A demethylation, highlighting FTO as a promising therapeutic target. #Epitranscriptomic
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could lactate-driven epigenetic changes shape cardiac recovery after #MyocardialInfarction?
This review explores histone lysine #lactylation and its interactions with other #PTMs in ischemia/reperfusion injury, revealing new targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...

Could #miRNAs help overcome #BreastCancer treatment resistance?
This review examines how miRNAs and anti-miRs regulate apoptosis and responses to #radiotherapy and chemotherapy, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Protecting the respiratory mucosa remains challenging.
This review explores #MucosalImmunity and next-generation #IntranasalVaccines, inhalable antibodies and broader antigen strategies to strengthen airway defense.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...