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Grilled Cheese is a product of Village Compute

Version devBuilt at: 2026-10-16 08:00:47 EDT

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@sigtrans-sttt.bsky.socialOct 12, 2026, 6:32 AM

Using comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress.

#STTT #OpenAccess: doi.org/10.1038/s413...

Phospholipid phosphatase 2 drives liver repair and regeneration after acute liver injury
@cddpress.bsky.socialOct 7, 2026, 11:34 AM

“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress”

Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️
nature.com/articles/s41...

@sigtrans-sttt.bsky.socialOct 1, 2026, 7:37 AM

This study uncovers how polymeric #Alpha1Antitrypsin accumulation perturbs Paneth cell #Proteostasis via #ERstress and impaired lysosomal clearance, linking deficiency to severe intestinal inflammation.

#STTT #OpenAccess: doi.org/10.1038/s413...

Polymeric alpha-1 antitrypsin perturbs Paneth cell proteostasis and exacerbates intestinal inflammation
@currentmedscience.bsky.socialSep 21, 2026, 1:49 PM

This study demonstrates that #CHOP deficiency intensifies inflammation, epithelial #apoptosis, and injury in OAB mice by suppressing #ERStress, pointing to CHOP as a therapeutic axis. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Urology

Chop Deficiency Exacerbates Cyclophosphamide-Induced Overactive Bladder via Impaired Macrophage Apoptosis