Can #radiotherapy delay lung cancer resistance?

Combining third-generation #EGFR inhibitors with radiotherapy was associated with longer median progression-free survival (13 vs. 18.1 months) in EGFR-mutated #NSCLC. @2024_HUST

#currentmedicalscience: doi.org/10.1007/s115...

Two cancer drivers, one targetable pathway.

#FOXM1 directly activates #CHEK1, driving #NSCLC growth and EMT, while CHEK1 suppression slows tumour progression, highlighting a promising therapeutic target.

#currentmedicalscience: doi.org/10.1007/s115...

Salt does more than raise blood pressure.

How excess salt triggers #hypertension remains unclear, but this study links high salt intake to #GutMicrobiome shifts and altered #ShortChainFattyAcids that may promote hypertension.

#currentmedicalscience: doi.org/10.1007/s115...

Why some cervical cancers become more aggressive remains unclear.

This study identifies TM4SF1 as a marker of poor prognosis that promotes #tumour spread and survival, highlighting a potential target for #CervicalCancer therapy.

#currentmedicalscience: doi.org/10.1007/s115...

#CancerBiomarkers

Cancer therapy shouldn't come at the cost of #HeartFailure.

This study identifies the miR-144-5p/ACSM1 pathway as a driver of #doxorubicin-related heart injury, revealing a strategy to protect cardiac function during chemotherapy.

#currentmedicalscience: doi.org/10.1007/s115...

Could #Salidroside overcome #paclitaxel resistance in lung cancer?

This study shows that it restores drug sensitivity in resistant #NSCLC cells by blocking Wnt/β-catenin signaling, suppressing proliferation and promoting apoptosis.

#currentmedicalscience: doi.org/10.1007/s115...
#LifeSciences

Can imaging predict outcomes in advanced #LungCancer?

This study combines CT-based #radiomics, peritumoral features and clinical biomarkers to improve progression-free survival prediction in patients receiving #chemoimmunotherapy.

#currentmedicalscience: doi.org/10.1007/s115...
#Biotechnology

Impurities can distort #ExtracellularVesicle size measurements.

This study shows that 1 μm PVDF filtration removes large particles and improves #DynamicLightScattering precision for more reliable EV characterization.
#currentmedicalscience: doi.org/10.1007/s115...

#medsky #Biotechnology

Early-onset #diabetes across generations may have a genetic basis.

This study identifies #PathogenicVariants in HNF1A, PDX1, KCNJ11 and WFS1, supporting precision diagnosis and treatment.
#currentmedicalscience: doi.org/10.1007/s115...

#GeneticCounseling #medsky

Could early recognition prevent vision loss from #OcularToxoplasmosis?

This study highlights #retinochoroiditis as the main presentation and the value of timely testing and treatment to reduce recurrence.
#currentmedicalscience: doi.org/10.1007/s115...

#AnteriorUveitis #medsky

A simple metabolic marker may signal heart risk.

This study links greater #InsulinResistance to a higher 10-year risk of #CardiovascularDisease, highlighting metabolic health as an important predictor of future heart events.

#currentmedicalscience: doi.org/10.1007/s115...
#medsky

#Hypoxia makes liver cancer harder to treat.

This study shows that 3-BrPA enhances arterial #embolization, suppressing tumor growth and promoting necrosis, offering a strategy to overcome hypoxic resistance.
#currentmedicalscience: doi.org/10.1007/s115...

#HepatocellularCarcinoma #LiverCancer

Defining predictive tools reshapes orthopedic surgery.

Dual stream attention networks predict #TibialPlateauFractures classifications with accuracy, automating assessment & supporting surgical planning. #medsky
Read: doi.org/10.1007/s115...

#currentmedicalscience #Orthopedics

Elevated NCAPD3 expression drives #HCC #metastasis. Inhibition impedes tumor growth and metastatic potential by blocking PI3K–AKT signaling, underscoring translational promise in #Oncology #medsky

Full article: doi.org/10.1007/s115...

#currentmedicalscience #DigitalHealth

GBDT, integrated with APACHE II, strengthens mortality prediction in acute #Gastrointestinal bleeding patients, delivering reliable prognostic insights for clinical decision support. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Gastroenterology #ClinicalAI

#Vitamin D activates Nrf2/HO-1 pathway to alleviate inflammation and injury after acute #CerebralInfarction, highlighting Nrf2’s role and VD’s therapeutic potential in #IschemicStroke. #medsky

Learn more: doi.org/10.1007/s115...

#currentmedicalscience #Neuroscience

This study highlights a DNN model that significantly improves #ParkinsonsDisease diagnosis accuracy using spiral & wave handwriting, outperforming ML/DL models & advancing future diagnostics. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Neurotechnology#MachineLearning

Findings underscore the critical need for targeted interventions in severe pediatric #MentalDisorders. Early detection & management are essential to mitigate long-term developmental impacts. #medsky

Read: doi.org/10.1007/s115...

#currentmedicalscience #Psychiatry #MentalHealth

#Bcl2 family proteins regulate cell survival and death, with roles spanning autophagy, calcium #homeostasis, and mitochondrial dynamics, offering therapeutic promise through BH3 mimetics. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #CellBiology

Can #Microglia hold the key to stroke defense?

Casr-related neuroprotection induced by ischemic preconditioning is linked to M2 microglial transformation, offering insight into #IschemicStroke defense. #medsky

Read: doi.org/10.1007/s115...

#currentmedicalscience #Neuroscience