TKI intolerance in chronic-phase CML: hold, reduce, or switch?

Dose optimization can often improve tolerability while preserving molecular response. Switch when toxicity is dangerous/refractory or response is lost.

Optimize the dose before changing the drug. #CML #Leukemia

Market views and stress tests on multiple horizons for fully general Monte Carlo path simulations.

Find the article and its accompanying Python code below.

#quant #quantsky #finance #markets #python #investing #investment #tailrisk #entropypooling #cvar #cml

How much extra performance can we expect from path-dependent tail risk optimization of a US equity sector strategy?

Find out in the Python case study below.

#quant #quantsky #finance #markets #python #investing #investment #talrisk #cvar #cml

In 1998, Mel Mann was told he had #CML and that he had three years to live.

Fast forward to 2026 ⏩ Mel's still healthy and training for his next marathon. 🏃

On this #WorldCMLDay, listen to Mel's story (via @npr.org):

Today is #WorldCMLDay! 🧡
9/22 represents the chromosomes involved in CML. Today we celebrate treatment advances & support the global CML community.
#CML #BCAM @cmlnet

💬 25 years ago, Andrea was diagnosed with chronic myeloid leukaemia. Her journey took her through clinical trials and bone marrow transplantation to a new chapter in life.

🌍 On this #WorldCMLDay, join us in raising awareness and showing support to people living with #CML. 🙏

#CureCML #PatientStory

💊 #PBPK #modeling replaced ≥10 clinical studies for asciminib (Scemblix®) NDA—bridging doses, predicting DDIs, and informing labels. A powerful case for #model-informed #drug #development!

📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML

Místico conserva su máscara tras vencer a Averno en el 93 Aniversario del CMLL

🤖 IA: No es clickbait ✅
👥 Usuarios: No es clickbait ✅

#cml #luchalibre #místico

👇👇👇

Inevitable Tessa title win is delayed for another big show #cml

Find my latest scientific quantitative investment research here.

#quant #quantsky #finance #markets #python #science #tailrisk #cvar #cml #montecarlo

Don’t ignore the mitochondria.

Sci Ed Charles de Bock talked to Dr. Ilaria Pagani about her recent HemaSphere paper that may change how you think about #CML. The message is clear: mitochondrial data may be a biomarker, not background noise.
Hear the full conversation: https://hsphere.pub/sms

Conditional Maximum Loss (CML) is a multi-period generalization of Conditional Value-at-Risk (CVaR).

CML accounts for the path-dependent tail risk between rebalancing times.

Find a Python case study of how it compares to CVaR in the Substack article below.

#quant #quantsky #finance #python #cml

Day 2267: Energy very low today! Being productive by getting a 10km in the bag #100daysofwalking #CML #365daysofwalking #leukaemia