To overcome tumor immune evasion, researchers engineered NK cells that target PD-L1, block NKG2A/HLA-E inhibitory signaling, and produce IL15 to improve antitumor activity, survival, and metabolic fitness.

#OpenAccess: doi.org/10.1038/s413...
#TumorImmunology #CellTherapy #ImmunoOncology

The scientific programme for the EANO-EORTC CNS Metastasis Meeting 2027 is taking shape and it reflects the multidisciplinary approach needed to tackle one of oncology's greatest challenges. Explore the programme and register today:
www.eano.eu/eanomeetings...
#CNSmetastasis2027 @eortc.org

ecDNA and the Genomic Chaos of Cancer | Virtual Event: 23-24 Feb 2027

Recent recognition of ecDNA’s enabling role as a hallmark of cancer, particularly as it results from genome instability, has highlighted the critical need to better understand its underlying biology.

eacr.org/conference/e...

📰 The Guardant360 CDx has received EU approval as a companion diagnostic to identify patients with ER+, HER2– locally advanced or metastatic breast cancer who may benefit from camizestrant. #bcsm #oncology

Full story ➡️: www.onclive.com/view/guardan...

Post-translational modifications can coordinate metabolic and immune adaptation in #Cancer. This review links PTM networks to metabolic flux, cell fate, #ImmuneEvasion, and emerging targets for metabolic therapy and #Immunotherapy.

#STTT #OpenAccess: doi.org/10.1038/s413...

How does immune cell trafficking shape tumors and #Inflammation?

This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.

#STTT #OpenAccess: doi.org/10.1038/s413...

How do intrinsic and acquired mechanisms drive cancer drug resistance?

This review details the mechanisms underlying resistance, highlighting emerging therapeutic strategies for overcoming resistance in #PrecisionOncology.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerResearch #Oncology

#Mitochondrial dysfunction contributes significantly to human disease pathogenesis.

This review connects #proteostasis, biogenesis, mitochondrial dynamics, and mitophagy with disease mechanisms and emerging therapeutic strategies. @ub.edu

#STTT #OpenAccess: doi.org/10.1038/s413...

#Mucosaltissues serve as primary pathogen entry points requiring specialized defenses.

A review of the immune mechanisms and #Vaccine delivery platforms that elicit local & systemic responses, as well as the challenges for next-gen #MucosalVaccines.

#STTT #OpenAccess: doi.org/10.1038/s413...

#TumorHeterogeneity challenges antigen-specific #Vaccination.

This review explores how in situ #CancerVaccines combine immunogenic cell death, advanced delivery, microenvironment modulation, and checkpoint blockade to broaden antitumor immunity.
#STTT #OpenAccess: doi.org/10.1038/s413...

How can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments?

This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

This review links genomic and #Epigenetic changes, metabolic adaptation, immune escape, and therapy-driven selection to emerging evolution-guided strategies for #PrecisionOncology. @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

🗞️ Just in: The phase 3 EXCALIBER-RRMM trial met its second dual primary end point, with iberdomide plus daratumumab/dexamethasone extending PFS vs DVd in patients with R/R multiple myeloma #mmsm #oncology

Read more: www.onclive.com/view/iberdom...

The EACR 2027 Congress Call for Abstracts is now online! Explore the abstract topics and start planning what you might present in Bilbao in June: 2027.eacr.org/abstracts

Submit an abstract by October 21 for the AACR Special Conference on Cancer Biology-informed Radioligand Therapy (January 7-10; San Diego), chaired by Kayvan Keshari, David Piwnica-Worms, Julie L. Sutcliffe, and David A. Tuveson.
buff.ly/gVPJ8ey
#aacrRLT27

ENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerStemness

Can light power stressed #Mitochondria? Engineered mt-EcGAPR uses ambient light to enhance ATP production and reduce ROS, suppressing ER stress–ATF6–GSDMD-mediated #Pyroptosis and protecting retinal ganglion cells.

#STTT #OpenAccess: doi.org/10.1038/s413...
#RetinalResearch #Neuroscience

#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis

#STTT #OpenAccess: doi.org/10.1038/s413...

#ArterialStiffness links vascular aging with #cardiovascular and end-organ damage. This review explores its structural and functional mechanisms, clinical measurement, and emerging strategies for personalized prevention and therapy.

#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine

New first-line strategies are needed for metastatic #ColorectalCancer. The APICAL-CRC phase II trial finds promising #antitumor activity and manageable safety with sintilimab plus anlotinib in treatment-naïve patients.

#STTT #OpenAccess: doi.org/10.1038/s413...
#MetastaticCRC #Immunotherapy