(BioRxiv All) Benchmarking the Performance of a Commercial Electrostatic Linear Ion Trap (ELIT) Charge Detection Mass Spectrometer For Higher-Order Antibody Aggregate Analysis: Higher-order antibody aggregates remain challenging to characterize using conventional mass… #BioRxiv #MassSpecRSS

(BioRxiv All) Optimization of Search and Acquisition Strategies for DSSO Crosslinking Mass Spectrometry using Protein Prospector and Touchstone.: Crosslinking mass spectrometry (XL-MS) enables residue-level characterization of protein-protein interactions (PPIs) in both… #BioRxiv #MassSpecRSS

(BioRxiv All) Structural Basis of γδ T-Cell Receptor Crosslinking and Activation by a Spontaneously Dimerized Fab: The {gamma}{delta} T-cell receptor ({gamma}{delta} TCR) mediates immune responses in {gamma}{delta}T-cells, playing crucial roles in immune defense, tissue… #BioRxiv #MassSpecRSS

(BioRxiv All) Subcellular spatial proteomics of the close animal relative, Capsaspora owczarzaki: Capsaspora owczarzaki is one of the closest relatives of animals and an increasingly tractable model for investigating the evolution of multicellularity. However, very little cell… #BioRxiv #MassSpecRSS

(BioRxiv All) Genus-wide re-speciation of Corynebacterium and genomic characterisation of 87 sinus isolates resolves taxonomic conflicts and identifies four candidate novel species: Corynebacterium species are common members of the sinonasal microbiome and have shown… #BioRxiv #MassSpecRSS

(BioRxiv All) The modulatory effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy-associated clearance in Aβ1-42-induced N2a cells: Background and objective: Alzheimers disease involves imbalanced amyloid-{beta} (A {beta}) production and clearance,… #BioRxiv #MassSpecRSS

(BioRxiv All) Climate change effects on terpene expression differ among populations and have consequences for herbivory in an invasive plant: ABSTRACT 1. Plant secondary metabolites often moderate interactions with abiotic and biotic factors. For example, secondary metabolites… #BioRxiv #MassSpecRSS

(BioRxiv All) Spatial Tumour Tissue Distribution Dynamics of a Bicycle Peptide-MMAE Toxin Conjugate Profiled by Targeted Mass Spectrometry: A highly specific-NECTIN-4 binding bicyclic peptide covalently linked to the cytotoxin monomethyl auristatin E (MMAE) via a… #BioRxiv #MassSpecRSS

(BioRxiv All) APEX2 proximity labeling maps the mGBP2-proximal proteome at the Toxoplasma gondii parasitophorous vacuole: Interferon-inducible guanylate binding proteins (GBPs) are large GTPases crucial for the host immune response against Toxoplasma gondii, a globally… #BioRxiv #MassSpecRSS

(BioRxiv All) The Human Contraceptive Antibody Targets A Semenogelin Galectin-3 N-Linked Glycan Complex on the Sperm Surface: The human contraception antibody (HCA) is a non-hormonal topical contraceptive entering Phase II clinical trials that functions by agglutinating and… #BioRxiv #MassSpecRSS

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(BioRxiv All) A monoallelic immunopeptidome atlas of 10 prevalent canine DLA-88 alleles: Characterization of naturally processed MHC class I (MHC-I)-bound peptides is essential for defining allele-specific peptide-binding features and understanding the functional consequences… #BioRxiv #MassSpecRSS

(BioRxiv All) DTCAMD, a disease-associated truncated form of CRYAB in neovascular age-related macular degeneration: a potential driver of subretinal fibrosis: Abstract Purpose: Subretinal fibrosis causes irreversible vision loss in neovascular age-related macular degeneration… #BioRxiv #MassSpecRSS

(BioRxiv All) Single Cell Proteomics reveals partial uncoupling of the Glycerol-3-Phosphate shuttle to compensate for Electron Transport Chain dysfunction in Alexander Disease GFAP mutations: Alexander disease (AxD) is a rare genetic leukodystrophy caused by dominant mutations… #BioRxiv #MassSpecRSS

(BioRxiv All) Spatial isotope tracing maps compartmentalized nutrient use across the adult fruit fly: Drosophila melanogaster is a powerful model for studying systemic metabolism. Although metabolism is compartmentalized across tissues, prior work in adult Drosophila has… #BioRxiv #MassSpecRSS

(BioRxiv All) Proteomic Characterization of Prostate Cancer Bone Metastasis Subtypes Defines Progressive Remodeling States of the Bone-Tumor Microenvironment: Prostate cancer (PC) bone metastases (PCBM) are a debilitating disease morbidity that primarily affects the axial… #BioRxiv #MassSpecRSS

(BioRxiv All) Pharmacokinetic properties of Ogerin and its regulation of post-ischemia signaling in mice: Ogerin, a positive regulator of GPR68, reduces infarct volume and attenuates blood-brain barrier (BBB) leakage post transient middle cerebral artery occlusion (tMCAO).… #BioRxiv #MassSpecRSS

(BioRxiv All) Pannexin 1 Ablation Disrupts Cell Cycle Progression and Compromises the Structure of Melanoma Tumours: Pannexin 1 (PANX1) is a channel-forming glycoprotein that has been implicated in regulating melanoma cell properties such as growth, migration, and invasion.… #BioRxiv #MassSpecRSS

(BioRxiv All) ATP synthase deficiency promotes prolonged hydrogenproduction in Chlamydomonas: Photosynthetic electron transport is tightly regulated to balance ATP and NADPH production and prevent over-reduction of the photosynthetic machinery. How this balance is maintained… #BioRxiv #MassSpecRSS

(BioRxiv All) mzQC: a versatile way to communicate quality information for biological mass spectrometry: Reliable quality control (QC) is essential for reproducible biological mass spectrometry, yet QC information is still typically stored in tool-specific, poorly… #BioRxiv #MassSpecRSS