@sigtrans-sttt.bsky.social#Exosome heterogeneity may shape chronic lung allograft dysfunction.
An integrated single-vesicle #Multiomic atlas identifies distinct graft exosome populations and links an Ilk-high subset to pleural thickening in chronic rejection.
@sigtrans-sttt.bsky.socialProtein #Lactylation connects cellular metabolism with #Epigenetic regulation.
This review examines its molecular machinery and functions across physiology and disease, highlighting #Biomarker and therapeutic potential.
@sigtrans-sttt.bsky.social#TumorHeterogeneity and #Immunosuppressive microenvironments hinder the treatment of #SolidTumors.
This review explores diverse immune and stem-cell platforms, alongside allogeneic and in vivo engineering strategies for broader cancer treatment.
@sigtrans-sttt.bsky.socialResearchers evaluate the novel PARP inhibitor prodrug TSL-1502 in a phase 2 trial, demonstrating promising antitumor activity in BRCA-mutated HER2-negative advanced breast cancer. #ClinicalTrial
#STTT #OpenAccess: doi.org/10.1038/s413...
#CellTherapy #CancerImmunotherapy
@sigtrans-sttt.bsky.social#WorldAlzheimersDay | September 21, 2026
#Alzheimer’s research is advancing understanding of neurodegenerative pathways and therapeutic targets. #STTT publishes peer-reviewed research advancing signaling biology, therapeutics and translational medicine.
Explore articles: www.nature.com/sigtrans/
@sigtrans-sttt.bsky.socialHow does #METTL3 drive pancreatic acinar cell carcinoma?
Researchers show that #RNAmethylation promotes tumor growth via m⁶A-dependent tumor programs and stromal crosstalk, while its inhibition triggers #Apoptosis.
@sigtrans-sttt.bsky.socialTargeting ROCK2 may offer a therapeutic approach for chronic graft-versus-host disease (#cGVHD). This phase Ib study finds encouraging responses and a manageable safety profile with TDI01, a highly selective ROCK2 inhibitor.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Fibrosis #TCellImmunity
@sigtrans-sttt.bsky.socialHow can #NSCLC escape #EGFR inhibition?
RAF1 amplification on extrachromosomal DNA reactivates MAPK signaling independently of EGFR, driving acquired erlotinib resistance and revealing a targetable mechanism.
#STTT #OpenAccess: doi.org/10.1038/s413...
#OncogeneAmplification #CancerGenomics
@sigtrans-sttt.bsky.socialResearchers show that β-cell-targeted #VEGF-A saRNA activation chimeras induce VEGF-A expression to accelerate vascular integration and improve islet #Transplantation outcomes in mouse and human islet #Grafts.
@sigtrans-sttt.bsky.socialResearchers discover that rapid transcriptional elongation and pause release induced by SEC-driven RNA pol II promote endothelial plasticity & plaque vulnerability, offering a #TherapeuticTarget for #Atherosclerosis.
@sigtrans-sttt.bsky.socialHow does #HCC withstand #OxidativeStress during therapy?
This study identifies a HIF1α–KLF4–hemoglobin axis that scavenges ROS and promotes sorafenib resistance, revealing a targetable redox adaptation.
@sigtrans-sttt.bsky.socialThis study identifies SCFJFK as an E3 ligase that mediates #RUNX2 degradation, and a reciprocal RUNX2–JFK feedback loop linking #Proteostasis to #Osteogenesis and the pathogenesis of #CleidocranialDysplasia. @pku1898.bsky.social
@sigtrans-sttt.bsky.socialThis review maps platelet signaling from hemostasis and #TissueRepair to immune regulation and disease, highlighting how dysregulated platelet activity contributes to #Thrombosis, #Cancer metastasis and #ChronicInflammation.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialDoxorubicin-treated #BreastCancer cells release exosomal miR-216a-5p that targets ITCH and activates TXNIP–NLRP3 signaling, revealing tumor–heart crosstalk that promotes cardiomyocyte #Pyroptosis and #CardiacInjury. @fudan-university.bsky.social
@sigtrans-sttt.bsky.socialEnhancing SIRT3 in nigral dopamine neurons preserves mitochondrial function and nigrostriatal #Dopamine activity, attenuating age-related motor decline while supporting muscle mass and #Neuromuscular integrity.
#STTT #OpenAccess: doi.org/10.1038/s413...
#HealthyAging #NeuromuscularHealth
@sigtrans-sttt.bsky.socialThis review maps viral oncogenesis from host-cell transformation and genomic instability to immune suppression and chronic #inflammation, connecting these mechanisms with evolving strategies to prevent and treat virus-related cancers.
@sigtrans-sttt.bsky.socialPRDX4 emerges as a switch for alveolar macrophage activation, with its oligomerization disrupting PTEN homodimerization and activating AKT–NF-κB signaling to promote inflammatory and #Profibrotic responses.
@sigtrans-sttt.bsky.socialPDR emerges as a heterogeneous disease with subtypes linked to immune defense against pathological endothelium or endothelial #MitochondrialDysfunction, while anti-#VEGF therapy influences both cellular compartments.
@sigtrans-sttt.bsky.socialThis review maps the HDAC family across health and disease, connecting their molecular functions in #inflammation, #metabolism and cell fate with the expanding development and clinical application of HDAC modulators.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerBiology #DrugDiscovery
