RegVelo integrates RNA velocity with gene regulatory networks to model single-cell dynamics more accurately. This innovative framework enhances understanding of cellular fate transitions by quantifying… PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #RNA 🧪

A genome-scale genetic interaction map in HAP1 cells reveals ~89,000 interactions, organizing genes into modules linked to protein complexes—key for targeted therapies! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering new enzymes with metal-coordination mining could transform enzyme prediction, linking genome insights to real-world applications. PMID:42386972, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10716-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta cycles sweep spatial paths, aiding navigation by directing behavior to goals. Theta sweeps are task-relevant for rapid planning. #NeuralDynamics PMID:42386948, Nat Neurosci 2026, @NatureNeuro @Cornell https://doi.org/10.1038/s41593-026-02364-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, impacting gene expression, evolution, and disease through regulatory roles at individual loci. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Disrupting specific TENT5 proteins can lead to infertility, providing new insights into the molecular mechanisms of gametogenesis and a foundation for further research into fertility disorders.

#IIMCB #Science #RNA #MolecularBiology #INMOLCELL

A study on GBM reveals that CAR T cell therapy shows tumor reduction and prolonged survival in recurrent cases, but relapse is frequent. Comprehensive profiling of immune responses post-therapy uncovers… PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #RNA 🧪

New study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular Fe²⁺ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium leads to increased nociceptive innervation and chronic pain, linked to SLC7A11 and glutamate signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

#RNA Atrium Therapeutics Announces $50 Million Private Placement

https://www.stocktitan.net/news/RNA/atrium-therapeutics-announces-50-million-private-atpd916ekil4.html?utm_source=stocktitan-bluesky&utm_medium=social

Teach #transcription with our paper model! Your students will be surprised at how fun it is to make a model & how easy it is to learn the content. Get them to make video to help with revision later! Find out more here: buff.ly/qICMY00

#genetics #DNA #RNA #modelmaking

Alphavirus M1, via NSP2, disrupts super-enhancer oncogenic transcription in osteosarcoma. Surprisingly, this isn’t just about ER stress or RPB1 involvement. PMID:42386745, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75013-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how plants respond to touch! A MAPKKK3/4/5-MKK4/5-MPK3/6 cascade is activated in 60s, inducing 800 genes—key for early mechanostimulation response. 🌿 PMID:42386747, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74994-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Visualizing #RNA dynamics in living plant cells at single transcript resolution is limited by high background fluorescence. This study develops a high signal-to-noise imaging platform that overcomes this barrier, revealing mRNA trafficking dynamics.
🧪 #AcademicSky #imaging #plants
plos.io/4ARoa5k

New tech D&D-seq maps DNA-protein interactions in single cells, revealing insights on TF binding and chromatin states, bridging gaps in gene expression control! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals that over 2,700 mRNA 3' UTRs with conserved sequences are key in regulating proteins like JMJD3, altering their folding and activity, not just abundance! #Proteins #Biology PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #RNA 🧪

AI-driven discovery of GPNMB CAR T cells unlocks multi-cancer therapy potential, refining targets via single-cell RNA sequencing from 10K+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Discover how quasisymmetric one-component protein nanocages can revolutionize biologics delivery with virus-like assemblies of 100s-1000s of subunits! 🚀 PMID:42162430, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10554-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature paper reveals replication stress causes chromatin loops to form, enclosing stalled forks at CTCF motifs, aiding genome integrity; join the convo! PMID:42386978, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African proteomic study unlocks Alzheimer's insights. Nigerian and Tanzanian cohorts reveal plasma profiles linked to amyloid pathology; breakthrough in ADRD research! PMID:42386726, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74971-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪