Study finds restoring cortical disinhibition reduces Huntington's symptoms. In-depth 2-photon imaging reveals roles of neuronal subtypes. HD movement disorder unravelled. PMID:42386967, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10671-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed a CRISPR knockout mouse library targeting 84 host genes for in vivo influenza A studies, paving the way for better understanding of viral pathogenesis. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila. Diallyl disulfide, a garlic compound, inhibits both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Prion-based switching of DNA repair proteins in Saccharomyces cerevisiae boosts mutagenesis rates, enabling rapid adaptation in diverse environments. Fascinating evolution insights! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA 🧪

Targeted TFO liposome (tLipo-TFO1) reduces PAI-1, addressing pulmonary fibrosis by enhancing ECM clearance. PMID:42385711, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00326-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metastasis in CRC is driven by tumor cell plasticity. TROP2, a marker linked to poor outcomes, associates with WNT^low and fetal-like states, fueling resistance. PMID:42386981, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10705-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists in hidradenitis suppurativa: study of mortality, CV events, and systemic complications in cohort. Discuss! 🔍 PMID:42384412, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1907 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals change: 1 in 4 women, 1 in 100 men face military sexual trauma. Treatment up but suicidal thoughts persist. PMID:42160071, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1203 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Casdatifan, a potent HIF-2α inhibitor, shows durable antitumor activity in refractory metastatic ccRCC per ARC-20 study (NCT05536141). Manageable safety. PMID:42386974, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10718-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to decode tumor microenvironments from H&E histopathology, analyzing 18M+ cells to uncover spatial habitat dynamics influencing therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that thousands of changes in spinal motor neurons signal a shift to a "disease-associated motor neuron" state in ALS, highlighting key transcription factors before cell death. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky 🧪

A genome-scale genetic interaction map in HAP1 cells reveals ~89,000 interactions, organizing genes into modules linked to protein complexes—key for targeted therapies! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering new enzymes with metal-coordination mining could transform enzyme prediction, linking genome insights to real-world applications. PMID:42386972, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10716-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta cycles sweep spatial paths, aiding navigation by directing behavior to goals. Theta sweeps are task-relevant for rapid planning. #NeuralDynamics PMID:42386948, Nat Neurosci 2026, @NatureNeuro @Cornell https://doi.org/10.1038/s41593-026-02364-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, impacting gene expression, evolution, and disease through regulatory roles at individual loci. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

JPET is planning a new special collection titled, "Computational Systems Pharmacology and Docking In Signal Pathways Analysis and Modulation for Neurodegenerative Diseases." Submissions are due March 15, 2027. Learn more: https://ow.ly/LRne50ZUXWP
#pharmsky 🧪

New study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular Fe²⁺ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium leads to increased nociceptive innervation and chronic pain, linked to SLC7A11 and glutamate signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Alphavirus M1, via NSP2, disrupts super-enhancer oncogenic transcription in osteosarcoma. Surprisingly, this isn’t just about ER stress or RPB1 involvement. PMID:42386745, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75013-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how plants respond to touch! A MAPKKK3/4/5-MKK4/5-MPK3/6 cascade is activated in 60s, inducing 800 genes—key for early mechanostimulation response. 🌿 PMID:42386747, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74994-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪