(BioRxiv All) Optimising MALDI on PEN substrates for small molecule analysis in the context of same-section multimodal workflows: Multimodal imaging workflows increasingly require multiple analytical techniques to be applied to the same tissue section to improve spatial… #BioRxiv #MassSpecRSS

Excited to share our latest preprint, “Serine/Threonine phosphatase PP1 is a regulator of Notch signalling.”

Kudos to Jiban Barman for leading this work in Dr. Rohit Joshi’s lab at @bric-cdfd.bsky.social. I am glad to be part of it!

#Drosophila #Notch #Neurobiology #bioRxiv

(BioRxiv All) Newly identified COPD GWAS protein interactors reveal a potential disease network module: Background: Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous disease influenced by genetic and environmental factors. However, the interactions… #BioRxiv #MassSpecRSS

(BioRxiv All) OpenLipid: a large language model workflow for targeted analysis of DIA mass spectrometry data in lipidomics: Mass spectrometry has become a central technology for lipidomics, with data-independent acquisition (DIA) enabling broad and reproducible sampling of… #BioRxiv #MassSpecRSS

(BioRxiv All) Multi-Modal Kinome Profiling Discovers Mesenchymal-Like Polarity Networks that Underly Directed Hepatocellular Carcinoma Cell Migration: Metastasis and associated therapy resistance remain the principal drivers of cancer related death, and there is a pressing… #BioRxiv #MassSpecRSS

(BioRxiv All) Fluorescence imaging-induced phospholipid oxidation drives membrane phase separation by shifting miscibility boundaries: Fluorescence microscopy is a widely used tool for visualizing membrane organization in model and cellular systems; however, photoexcitation… #BioRxiv #MassSpecRSS

(BioRxiv All) Ganglioside profiling by ion mobility and mass spectrometry imaging identifies distinct biomolecular isomers in Niemann-Pick Disease: Gangliosides are glycosphingolipids implicated in the neurodegenerative pathology of Niemann-Pick disease type C2 (NPC2 disease),… #BioRxiv #MassSpecRSS

(BioRxiv All) Evolutionary diversification of the nuclear pore complex in Entamoeba histolytica reveals conserved and lineage-specific nucleoporins: Nuclear pore complexes (NPCs) are the gateways for macromolecular exchange between the nucleus and cytoplasm. Although NPC… #BioRxiv #MassSpecRSS

(BioRxiv All) Dual-Binding Scaffold RRsS1 Bridges Pol IV Transcripts and DNA Templates for Robust Reproductive siRNA Biogenesis: Cytosine DNA methylation established by RNA-directed DNA methylation (RdDM) is critical for transposon silencing and genome integrity in plants. In… #BioRxiv #MassSpecRSS

(BioRxiv All) Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans: Secondary bacterial metabolites can regulate animal physiology, but the specific bacterial genes and molecules responsible for regulating, synthesizing, and transporting these molecules… #BioRxiv #MassSpecRSS

(BioRxiv All) An in vivo chemical genetic approach for targeted glycoproteome analysis in Drosophila melanogaster: Glycans impact every aspect of physiology. Despite the rapid increase in relevance and translational potential, there remains a lack of tools for studying… #BioRxiv #MassSpecRSS

(BioRxiv All) Chemically induced USP21-KLHL12 association recruits USP21 to COPII assembly: Ubiquitin-specific protease 21 (USP21) is a deubiquitinase implicated in various biological processes and disease states, including cancer. To better understand USP21 protein… #BioRxiv #MassSpecRSS

(BioRxiv All) Age-related differences in metabolome composition in a healthy pediatric population: A pilot analysis: Metabolic profiling of biofluids provides a comprehensive overview of physiological processes occurring at the molecular, cellular, tissue, and organ levels.… #BioRxiv #MassSpecRSS

(BioRxiv All) stably: error-controlled stability selection for biomarker panel discovery: Motivation Data-independent acquisition mass spectrometry (DIA-MS) has become increasingly popular for clinical proteomics due to its sensitivity and reproducibility. Univariate… #BioRxiv #MassSpecRSS

(BioRxiv All) Multi-omics Reveals Divergent Endothelial Molecular Responses to New and Old World Hantaviruses: Hantaviruses cause vascular leakage syndromes that vary in clinical manifestation and severity. Although tissue tropism contributes to these differences, both Old and… #BioRxiv #MassSpecRSS

(BioRxiv All) Temporal proximity proteomics reveals ANP32A roles in replication fork progression and end joining: Acidic nuclear phosphoprotein 32 family member A (ANP32A) regulates chromatin and histone homeostasis, but its contribution to DNA replication and repair remains… #BioRxiv #MassSpecRSS

Did you know that @biorxiv-medrxiv.bsky.social posts weekly to share updates and features that can help you make the most out of your preprint? Follow us there to learn how to leverage preprints to their fullest potential. #preprints #openscience #openrxiv #biorxiv #medrxiv

(BioRxiv All) Profiling proteome-level amino acid substitutions in Alzheimer's disease brain tissue: As the most prevalent neurodegenerative disorder worldwide, Alzheimer's disease (AD) remains incompletely understood at the proteome level. In particular, current studies on… #BioRxiv #MassSpecRSS

(BioRxiv All) The protein and lipid compositions of brain apolipoprotein E particles are cell type-specific: Genetic variation in APOE, which encodes a lipid transporter apolipoprotein E (apoE), is the strongest risk factor for late-onset Alzheimer's disease (AD). Although… #BioRxiv #MassSpecRSS

(BioRxiv All) Site-resolved spatial and structural interactome of a human cell: The spatial and structural arrangement of proteins determine virtually every process in human cells. We combined gentle subcellular fractionation by differential ultracentrifugation with… #BioRxiv #MassSpecRSS