Targeted TFO liposome (tLipo-TFO1) reduces PAI-1, addressing pulmonary fibrosis by enhancing ECM clearance. PMID:42385711, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00326-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metastasis in CRC is driven by tumor cell plasticity. TROP2, a marker linked to poor outcomes, associates with WNT^low and fetal-like states, fueling resistance. PMID:42386981, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10705-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists in hidradenitis suppurativa: study of mortality, CV events, and systemic complications in cohort. Discuss! 🔍 PMID:42384412, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1907 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals change: 1 in 4 women, 1 in 100 men face military sexual trauma. Treatment up but suicidal thoughts persist. PMID:42160071, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1203 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Casdatifan, a potent HIF-2α inhibitor, shows durable antitumor activity in refractory metastatic ccRCC per ARC-20 study (NCT05536141). Manageable safety. PMID:42386974, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10718-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to decode tumor microenvironments from H&E histopathology, analyzing 18M+ cells to uncover spatial habitat dynamics influencing therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Authors of @hggadvances.bsky.social's latest article introduce endoPRS-SS, an extension that enables PRS inference using GWAS & demonstrate that it maintains the predictive accuracy of endoPRS while increasing computational efficiency up to 90-fold: https://bit.ly/471JM1m #ASHG #humangenetics

A genome-scale genetic interaction map in HAP1 cells reveals ~89,000 interactions, organizing genes into modules linked to protein complexes—key for targeted therapies! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@konradjk.bsky.social & colleagues of @ajhgnews.bsky.social's latest article introduce ALLSPICE, a new framework for identifying cross-phenotype effect-size heterogeneity and resolving the architecture of rare variant pleiotropy: https://bit.ly/4y3PHOA #ASHG #humangenetics

Discovering new enzymes with metal-coordination mining could transform enzyme prediction, linking genome insights to real-world applications. PMID:42386972, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10716-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta cycles sweep spatial paths, aiding navigation by directing behavior to goals. Theta sweeps are task-relevant for rapid planning. #NeuralDynamics PMID:42386948, Nat Neurosci 2026, @NatureNeuro @Cornell https://doi.org/10.1038/s41593-026-02364-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, impacting gene expression, evolution, and disease through regulatory roles at individual loci. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular Fe²⁺ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium leads to increased nociceptive innervation and chronic pain, linked to SLC7A11 and glutamate signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Alphavirus M1, via NSP2, disrupts super-enhancer oncogenic transcription in osteosarcoma. Surprisingly, this isn’t just about ER stress or RPB1 involvement. PMID:42386745, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75013-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how plants respond to touch! A MAPKKK3/4/5-MKK4/5-MPK3/6 cascade is activated in 60s, inducing 800 genes—key for early mechanostimulation response. 🌿 PMID:42386747, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74994-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New tech D&D-seq maps DNA-protein interactions in single cells, revealing insights on TF binding and chromatin states, bridging gaps in gene expression control! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells unlocks multi-cancer therapy potential, refining targets via single-cell RNA sequencing from 10K+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Discover how quasisymmetric one-component protein nanocages can revolutionize biologics delivery with virus-like assemblies of 100s-1000s of subunits! 🚀 PMID:42162430, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10554-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature paper reveals replication stress causes chromatin loops to form, enclosing stalled forks at CTCF motifs, aiding genome integrity; join the convo! PMID:42386978, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪