TransCode Therapeutics Makes Significant Patent Advances in Australia and Japan for RNA-Based Cancer Therapies #None #Immuno-Oncology #TransCode #RNA

Cisplatin, a cancer treatment, induces neurotoxicity. NER helps neurons remove DNA damage but paradoxically leads to cell death. Understanding this may aid neuroprotection. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

September 22, 2026
👉 After three decades of research, a first therapeutic option for Alexander disease is finally available.
🙂 Another encouraging news from Groupe UIG.
Read: medicalxpress.com/news/2026-09...
#RNA #LifeSciences #Innovation #FDA #GroupeUIG #CarlBaillargeon

First up, our keynote speaker Katharina Höfer, wo recently moved to the Leibniz Institute for Immunotherapy in Regensburg. She talks about covalent RNA-Protein networks and their role in phage infection

#Infect-Net #RNA #NAD-RNA #Phages

Cysteine's sulfur directs CD8⁺ T cell metabolism, splitting between glutathione and iron-sulfur clusters, fueling 3 key processes: proliferation, function, and 2x anti-tumor immunity! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA 🧪

Cells exhibit polarization and migrate toward electrical fields. Belliveau et al. reveal TMEM154/Galvanin as a receptor that senses these gradients, guiding cells to the cathode. These findings enhance… PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #RNA 🧪

Large models like GPT-5 & Gemini show promise in health AI but can falter under simple stress tests, revealing key growth areas. PMID:42362863, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04501-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Check out PlanarFold: a new RNA model boosting simulation speed by over 10,000x with 2D coarse-grained dynamics, offering insights into RNA structures & dynamics! PMID:42362537, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74729-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational discovery led to small-molecule PAK1 activators, revealing a novel site for autoinhibition release, advancing cardiac therapy prospects. PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain are crucial for sustaining attention, challenging prior views on cholinergic neurons. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪

Re-admin of AAV1-hOTOF gene therapy, even amid peak NAb titers in Otof^-/- mice, improves OTOF-related deafness outcomes. PMID:42362868, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04505-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cliramitug's long-term follow-up in trial NI006-101 shows lasting safety and efficacy with dose-dependent amyloid reduction in ATTR-CM patients over 12 months. PMID:42362866, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04487-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Late embryonic skin injuries can regenerate diverse tissues effectively, but this capacity diminishes post-birth, leading to hyperinnervation and incomplete healing. PMID:41864207, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00234-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study tackles disparities in dementia diagnosis: 7,847 participants reveal inconsistent machine learning performance across racial/ethnic groups, urging better fairness insights. PMID:42362543, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74515-w #Medsky #Pharmsky #RNA #ASHG 🧪

New research identifies MARCH7 as a key E3 ubiquitin ligase that stabilizes iron homeostasis, reducing ferroptosis via K48-linked ubiquitylation of NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New in #OAC!
Schwab et al. aimed to develop a method to selectively study the zone of calcified #cartilage (ZCC) for gene expression analysis and transcriptomic studies. Learn how 3D microtomy was used to isolate #RNA from fresh human ZCC!
🔗
www.sciencedirect.com/science/arti...

How can a single antibiotic halt translation across all domains of life? 🧬

Our new study in Nucleic Acids Research reveals how Sparsomycin traps active ribosomes through a conserved mechanism.
academic.oup.com/nar/article/...

#Ribosome #Translation #StructuralBiology #Antibiotics #RNA #iTPseq

Study shows that accumbal dopamine predicts preference: 2 types of reward cues trigger DA transients in 100% cases, declining at natural rewards and persisting with drugs. PMID:42362884, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02331-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Humans evaluate info by relative evidence, not absolute uncertainty. AI models predict behavior. Fascinating insights! 🌟 PMID:42362882, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02342-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel in vivo gene switch responsive to electromagnetic fields (EMFs) allows precise spatiotemporal gene expression control. Key findings reveal Cyb5b as an essential EMF sensor. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG 🧪